2-芳甲酰氨基硫羰基-3-异噻唑酮及4-氰基-5-甲硫基-2-芳甲酰氨基硫羰基-3-异噻唑酮的合成与生物活性  

Syntheses and Biological Activities of 2Arylamidothioacyl3isothiozolones and 4Cyano5methylthio 2arylamidothioacyl3isothiozolones

作　　者：杨小平[1] 李正名[1] 陈寒松[1] 刘洁[1] 李树正[1] 

机构地区：[1]南开大学元素有机化学国家重点实验室,南开大学元素有机化学研究所

出　　处：《高等学校化学学报》1999年第3期395-398,共4页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金

摘　　要：通过３－羟基异噻唑（４）和４－氰基－５－甲硫基－３－羟基异噻唑（５）分别与芳酰基异硫氰酸酯（３）反应，合成标题化合物２－芳甲酰氨基硫羰基－３－异噻唑酮（６ａ＿６ｆ）和４－氰基－５－甲硫基－２－芳甲酰氨基硫羰基－３－异噻唑酮（７ａ＿７ｅ），对此反应及产物的结构特点进行了探讨．对部分化合物进行了杀菌活性测定。Novel compounds, 2arylamidothioacyl3isothiozolones 6 and 4cyano5methylthio2arylamidothioacyl3isothiozolones 7Z] were synthesized by reacting of 3hydroxyisothiozoles( 4, 5 ) with aryl isothiocyanates 3 . The unique coupling constants of 4H and 5H of isothiazole ring of compounds 6 were discovered and explained according to the coplanarity of isothiazole ring with thioacyl group. The preliminary test of fungicidal activity showed that some of the title compounds possessed promising activity.

关 键 词：酰基硫脲 合成 杀菌活性 生物活性 异噻唑酮 

分 类 号：TQ450.21[化学工程—农药化工]