降钙素原在指导慢性阻塞性肺疾病急性加重期抗感染治疗中的价值  

Value of procalcitonin in guiding the treatment for acute exacerbation of chronic obstructive pulmonary disease

作　　者：曾雪峰[1] 陈锋[1] 刘楠[1] 谢珊[1] 李凯[1] 王晓霞[1] 

机构地区：[1]成都市第三人民医院呼吸科,610031

出　　处：《实用医学杂志》2010年第22期4093-4095,共3页The Journal of Practical Medicine

基　　金：四川省卫生厅科研基金资助(编号:090047)

摘　　要：目的:评价降钙素原(PCT)在指导慢性阻塞性肺疾病急性加重期(AECOPD)抗感染治疗中的价值。方法:本研究纳入52例AECOPD患者,随机分成PCT组和常规治疗组。PCT组根据血清PCT水平决定抗生素的使用;常规治疗组根据患者临床症状决定抗生素的使用。主要观察指标为抗生素的使用时间、住院时间、临床有效率,加重例数和死亡例数等。结果:PCT组的抗生素使用时间多分布在7～10d;而常规治疗组大部分在2周甚至更长,差异有显著性,两组患者住院时间相比差异具有显著性,两组临床有效率、死亡率和加重例数无显著性差异。结论:PCT具有指导AECOPD抗菌治疗的作用,能够减少抗生素使用,缩短住院时间。Objective To evaluate the value of procaleitonin （PCT） in guiding the therapy for acute exacerbation of chronic obstructive pulmonary disease （AECOPD）. Methods 52 patients with AECOPD were randomized into PCT group, who received antibiotic treatment according to the serum level of PCT, and standard-therapy group, who received antibiotic treatment according to the clinical symptoms. The length of antibiotic exposure, clinical recovery rate, length of hospitalization, and death and exacerbation rates were recorded. Results The length of antibiotic exposure in PCT group was 7-10 days, while that in standard- therapy group was more than 2 weeks （P 〈 0.05）. There was a significant difference of the length of hospitalization between the two groups （P 〈 0.05）. Conclusions Proealeitonin guidance for AECOPD can reduce the dose of antibiotic drugs and the length of hospitalization.

关 键 词：肺疾病 慢性阻塞性 降钙素原 感染 

分 类 号：R563.9[医药卫生—呼吸系统]