多波长K系数法测定氯芬待因复方片剂的含量  

Assay of Diclofenac Sodium and Codeine Phosphate in Tablet by Multiwavelength K Factor Spectrophotometry

作　　者：张兰桐[1] 和悦 王春英 周月绵 张爱华 刘伟娜[1] 张振华 

机构地区：[1]河北医科大学药学院药物分析教研室

出　　处：《光谱学与光谱分析》1999年第3期476-477,共2页Spectroscopy and Spectral Analysis

摘　　要：本文报道了多波长Ｋ系数法测定氯芬待因复方片剂中双氯芬酸钠、磷酸可待因两组分含量的研究。结果表明，双氯芬酸钠在１１．１８～２５．４０μｇ／ｍＬ、磷酸可待因在６．７８５～１５．４２μｇ／ｍＬ范围内ΔＡ值与浓度线性关系良好，回归方程分别为ΔＡ双＝－０．００６７４ｃ双－１．４１８５×１０－３，ｒ＝０．９９９６；ΔＡ＝－０．０１３０ｃ可－１．８２２×１０－３，ｒ＝０．９９９８。双氯芬酸钠和磷酸可待因的平均回收率及相对标准偏差分别为１００．１％，０．３６％；１００．７％，０．８０％。方法简便，快速，结果满意。Assay of diclofenac sodium and codeine phosphate in tablet is reported in this paper.The calibration curves were linear over the range of 11 18 25 40 μg/mL of dicldofenac sodium and over the range of 6 785-15 42 μg/mL of codeine phosphate.The avarage racoveries and relative standard deviations of diclofenac sodium and codeine phosphate were 100 1 %,0 36% and 100 7%,0 80 %,respectively. The method is simple and rapid,and the results are satisfactory.

关 键 词：双氯芬酸钠 磷酸可待因 氯芬待因 复方片剂 测定 

分 类 号：R971.3[医药卫生—药品]