Design,synthesis and antitumor activity of a series of novel coumarin-stilbenes hybrids,the 3-arylcoumarins  

作　　者：Chun Fen Xiao Li Yang Tao Hong Yi Sun Wen Wei Yu Chen Li Wu Fu Yong Zou 

机构地区：[1]Gttangzhou Institute of Chemistry, Chinese Academy of Sciences, Guangzhou 510650, China [2]Graduated School of Chinese Academy of Sciences, Beijing 100049, China [3]Oncology Research Department of Sun Yat-Sen University Cancer Center, Guangzhou 510060, China

出　　处：《Chinese Chemical Letters》2010年第11期1295-1298,共4页中国化学快报（英文版）

基　　金：National Key Technology R&D Program,Science and Technology Program of Guangdong Province and Strategic Cooperation Program between Guangdong Province and Chinese Academy of Sciences,PR China(Nos. 2007BAD82B02,2006B35604002,and 2009B091300125) for financial support

摘　　要：A series of novel coumarin-stilbenes hybrids called 3-arylcoumarins were synthesized via Perkin reaction and evaluated as potential antitumor agents.The results showed that some compounds exhibited in vitro activity against KB,KV,MCF-7,MCF-7/ ADR cell lines to some extent.Compound 3a showed remarkable effect against KB tumor cells with an IC50 value of 5.18μmol/L.A series of novel coumarin-stilbenes hybrids called 3-arylcoumarins were synthesized via Perkin reaction and evaluated as potential antitumor agents.The results showed that some compounds exhibited in vitro activity against KB,KV,MCF-7,MCF-7/ ADR cell lines to some extent.Compound 3a showed remarkable effect against KB tumor cells with an IC50 value of 5.18μmol/L.

关 键 词：Perkin reaction 3-Arylcoumarin TRANS-STILBENE Antitumor activity 

分 类 号：TQ463.5[化学工程—制药化工] TQ334.9