脑出血大鼠血清白蛋白水平与肠黏膜变化的关系  

Correlation between serum albumin level and intestinal mucosa change in rats with cerebral hemorrhage

作　　者：王建林[1] 张苏明[2] 杨志秀[1] 张晓敏[1] 范云虎[1] 王静梅[1] 

机构地区：[1]云南省第二人民医院神经内科,昆明650021 [2]华中科技大学同济医学院同济医院神经内科

出　　处：《中华神经科杂志》2010年第11期801-804,共4页Chinese Journal of Neurology

摘　　要：目的 探讨脑出血大鼠血清白蛋白水平与空肠黏膜形态学之间的关系.寻找导致低蛋白血症的机制.方法 制作脑出血大鼠模型.检测正常对照组、假手术组及脑出血组术后1、7、14 d（每组8只）血清白蛋白水平与空肠黏膜形态学的参数.进行血清白蛋白水平与空肠黏膜形态学的参数值之间的相关分析.结果 血清白蛋白与小肠绒毛高度（r=0.869,P＜0.01）、绒毛面积（r=0.659,P＜0.01）、黏膜厚度（r=0.915,P＜0.01）、肠腺深度（r=0.545,P＜0.05）及肠腺密度（r=0.475,P＜0.05）呈正相关.结论 血清白蛋白水平与空肠黏膜形态学变化的关系密切.Objective To explore the correlation between the serum albumin level and the jejunal mucosal morphology in rats with cerebral hemorrhage and to find out the mechanism of the resulting hypoproteinemia.Methods A rat model of cerebral hemorrhage was used to detect the serum albumin level and the morphologic parameters of jejunal mucosa on day 1,7 and 14 after the hemorrhage.The results were compared to the normal control group and the sham-operated group. The correlation between the serum albumin level and the parameters of the jejunal mucosal morphology was explored.Results The serum albumin level was positively correlated with the small intestinal villous height（r =0.869,P〈0.01）,villous area（r=0.659,P〈0.01）,mucosal thickness （r=0.915,P〈0.01）,depth of intestinal glands（r=0.545,P〈0.05）and density of intestinal glands（r=0.475,P〈0.05）.Conclusion The serum albumin level is closely related to the morphologic changes of the jejunal mucosa.

关 键 词：脑出血 血清白蛋白 肠黏膜 大鼠 

分 类 号：R686[医药卫生—骨科学]