Perfluorooctane sulfonate and perfluorooctanoic acid in the fingernails of urban and rural children  

作　　者：XU Lei LIU Wei JIN YiHe 

机构地区：[1]Key Laboratory of Industrial Ecology and Environmental Engineering of Ministry of Education, School of Environmental Science and Technology,Dalian University of Technology, Dalian 116024, China

出　　处：《Chinese Science Bulletin》2010年第33期3755-3762,共8页

基　　金：supported by the Key Laboratory of Industrial Ecology and Environmental Engineering of Ministry of Education and Program for Chang-jiang Scholars and Innovative Research Team in University(IRT0813)

摘　　要：Perfluorooctane sulfonate(PFOS)and perfluorooctanoic acid(PFOA)are two typical perfluorinated compounds(PFCs),found in a wide range of environmental media and organisms,including humans.Human biomonitoring studies of body fluids have revealed that in many areas of the world the general population has been exposed to background levels of PFOS and PFOA.Fingernail has been suggested as a promising biopsy material for assessment of PFCs environmental exposure.In the present study,PFOS and PFOA were quantified using high performance liquid chromatography-tandem mass spectrometry(HPLC-MS/MS)in fingernails of urban and rural children(N=93)aged 6-12 years.A questionnaire was conducted to determine factors that could influence the PFOS and PFOA levels in the children.The levels of PFOS in urban children were significantly higher(geometric mean(GM)=328 ng/g)than those in rural children(GM=27 ng/g).In contrast,PFOA levels were significantly lower in the urban children compared with the rural children.Significant positive correlation(R=0.53,P<0.05 for urban areas;R=0.71;P<0.001 for rural areas)between the PFOS and PFOA concentrations indicated they had similar sources.The PFOS and PFOA levels were higher in fingernail samples from children aged <9 years than in children aged ≥9 years.In addition,females had higher PFOA levels than males,in both regions.Other factors that significantly influenced PFOS and PFOA levels were dietary habits and socio-economic background.The results of this study indicate fingernails are a suitable material for biomonitoring of PFCs environmental exposure.However,the levels determined in the fingernail samples need to be first evaluated with regard to the levels determined in other samples,such as human serum.Perfluorooctane sulfonate （PFOS） and perfluorooctanoic acid （PFOA） are two typical perfluorinated compounds （PFCs）, found in a wide range of environmental media and organisms, including humans. Human biomonitoring studies of body fluids have re- vealed that in many areas of the world the general population has been exposed to background levels of PFOS and PFOA. Fin- gernail has been suggested as a promising biopsy material for assessment of PFCs environmental exposure. In the present study, PFOS and PFOA were quantified using high performance liquid chromatography-tandem mass spectrometry （HPLC-MS/MS） in fingernails of urban and rural children （N=93） aged 6-12 years. A questionnaire was conducted to determine factors that could influence the PFOS and PFOA levels in the children. The levels of PFOS in urban children were significantly higher （geometric mean （GM）=328 ng/g） than those in rural children （GM=27 ng/g）. In contrast, PFOA levels were significantly lower in the urban children compared with the rural children. Significant positive correlation （R=0.53, P〈0.05 for urban areas; R=0.71; P〈0.001 for rural areas） between the PFOS and PFOA concentrations indicated they had similar sources. The PFOS and PFOA levels were higher in fingernail samples from children aged 〈9 years than in children aged ≥9 years. In addition, females had higher PFOA levels than males, in both regions. Other factors that significantly influenced PFOS and PFOA levels were dietary habits and socio-economic background. The results of this study indicate fingernails are a suitable material for biomonitoring of PFCs envi- ronmental exposure. However, the levels determined in the fingernail samples need to be first evaluated with regard to the levels determined in other samples, such as human serum.

关 键 词：城市地区 农村地区 全氟辛烷 全氟辛酸 儿童 指甲 磺酸 高效液相色谱 

分 类 号：TQ222.213[化学工程—有机化工] TQ225.241