处方成份对安乃近直肠吸收影响的研究  

INFLUENCE OF PRESCRIPTION COMPONENT ON RECTAL ABSORPTION OF ANALGIN IN MICROENEMA ANALGINI COMPOSITUM

作　　者：王章阳[1] 王亮明[2] 孟晓红[1] 廖工铁[2] 

机构地区：[1]第三军医大学西南医院,重庆400038 [2]华西医科大学药学院,成都610041

出　　处：《中国医药工业杂志》1999年第7期295-299,共5页Chinese Journal of Pharmaceuticals

摘　　要：采用一阶导数分光光度法及离子对萃取分光光度法测定了微型灌肠剂中安乃近（１）与盐酸氯丙嗪（２）的含量，线性范围分别为５～３０μｇ／ｍ ｌ（回收率１００．５４％ ，ＲＳＤ＝ １．０９％ ）与２０～１４０μｇ／ｍ ｌ（回收率１００．４０％ ，ＲＳＤ＝ １．５５％ ）。用大鼠在体直肠灌注剩余量法，考察了该灌肠剂中２、明胶（３）对１ 直肠吸收的影响。逐步回归分析表明，２ 在０～１％ 浓度范围内促进１ 的吸收，３ 在０～１０％浓度范围内呈相反作用。First order derivative spectrophotometric and ion pair extraction spectrophotometric methods were developed to measure concentrations of analgin(1) and chlorpromazine hydrochloride (2) in microenema analgini compositum. The liner ranges for the measurement of 1 and 2 were 5~30 μg/ml and 20~140 μg/ml, with mean recovery of 100.54% ( RSD =1.09%, n =18) and 100.40%( RSD =1.55%, n =8). The experiment about the influence of 2 and gelatin(3) on rectal absorption of 1, which based on the method of measuring the leaved amount of analgin after injecting microenema analgini compositum into rectum for 90 min, was arranged by uniform design. The last trial result dealed with step by step regression analysis showed that the absorbed amount of analgin in 90 min by rectum had good linear relationship with the concentration of both 2(0~1.0%) and 3(0~10%). It was discovered that 2 had the ability of enhancing the rectal absorption for analgin. The action of 3 was opposite.

关 键 词：安乃近 盐酸氯丙嗪 直肠吸收 微型灌肠剂 

分 类 号：R971.1[医药卫生—药品]