复方七芍降压片对SHR血压、心脏的影响  

Effect of Qishao Jiangya compound teblets on blood pressure and heart in spontaneously hypertensive rats

作　　者：张稳[1] 唐莹[1] 谭胜真[2] 雍苏南[1] 何泽云[1] 谭元生[1] 

机构地区：[1]湖南中医药大学第一附属医院,湖南长沙410007 [2]南华大学第一附属医院,湖南衡阳421001

出　　处：《湖南中医药大学学报》2010年第9期67-69,共3页Journal of Hunan University of Chinese Medicine

基　　金：湖南省自然科学基金资助项目(07JJ3050);湖南省科技厅基金项目(2007FJ3006);湖南省中医管理局基金项目(06201-52)

摘　　要：目的探讨复方七芍降压片的降压效果及作用机制。方法以12只14周龄正常血压WKY大鼠为阴性对照,设为空白组;60只14周龄自发性高血压大鼠(spontaneously hypertensive rats,SHR)随机分为5组,设为复方七芍降压片高剂量组、中剂量组、低剂量组、卡托普利组、硫酸氢氯吡格雷片组;分别采用大鼠尾动脉法测血压,观察用药后各组大鼠心脏的形态、颜色、质地、病变特征,测左心室质量指数。结果给药4周后,各组治疗前后比较,复方七芍降压片高、中、低剂量组与卡托普利组均能够降低SHR血压,差异有统计学意义(P<0.01),其中复方七芍降压片高剂量组疗效显著;均可降低左心室质量指数,差异有统计学意义(P<0.05);硫酸氢氯吡格雷片组及空白组对SHR血压无明显影响(P>0.05)。结论复方七芍降压片能有效降低SHR血压、逆转左心室肥厚。Objective To explore the effect and mechanism of Qishao Jiangya compound teblets（QJCT） on lowering blood pressure.Method 12 Wistar-kyoto（WKY） rats were used as negativde control group,and 60 spontaneously hypertensive rats（SHR） were divided randomly into 5 groups,namely high,middle and low QJCT doses group,Captopril group and Clopidogrel bisulfate tabletsgroup.The blood pressure was measured in tail artery,and the shape,color,texture and pathological feature of heart after treatment were observed,and then,the left ventricular mass index（LVMI） was measured.Results After treatment 4 weeks,the differences of lowering Bp between the before and after treatment in each group were significant also（P0.01）,in which,the effect in high QJCT doses group was obvious;and of lowering LVMI were significant（P 0.05）.Compound QJCT can effectively descend the BP and reverse the left ventricle hypertrophy.

关 键 词：复方七芍降压片 SHR 血压 LVMI 大鼠 

分 类 号：R285.5[医药卫生—中药学]