非甲～庚型肝炎患者中TTV感染的研究  

The Detection of TT Virus in Patients with Non AG Hepatitis

作　　者：宋建新[1] 田德英[1] 雷洪波[1] 陈红云[1] 

机构地区：[1]同济医科大学附属同济医院传染科

出　　处：《临床内科杂志》1999年第4期197-198,共2页Journal of Clinical Internal Medicine

摘　　要：目的检测ＴＴＶ－ＤＮＡ在非甲～庚型肝炎病人中的感染状况。方法采用巢式聚合酶反应检测３８例非甲～庚型肝炎病人血清中ＴＴＶ－ＤＮＡ并观察与肝功能的关系。结果３８例非甲～庚型肝炎病人中１６例ＴＴＶ－ＤＮＡ阳性，占４２．１％，其中，７例急性黄疸型肝炎病人ＴＴＶ－ＤＮＡ阳性率为７１．４％，明显高于总体水平，部分病例ＴＴＶ－ＤＮＡ随肝功能恢复而阴转。结论非甲～庚型肝炎病人中存在ＴＴＶ感染，而且可能与肝功能损害有关。Objective To detect TTV(transfusion transmitted virus)DNA in sera isolated from patients with non AG hepatitis. Methods A nested polymerase chain reaction(PCR)assay was established to detect TTVDNA in 38 patients with non AG hepatitis and its association with liver function. Results TTVDNA was positive in 16 of 38 paticnts (421%)with non AG hepatitis.Among them the positive rate in 7 patients with acute hepatitis was 741%,significantly higher than total level.And in part of the patients,the TTVDNA became negative following the recovery of liver function. Conclusion This study confirmed the existence of TTV infection in patients with non AG hepatitis,and implicated that it probably correlated with the impairment of liver function.

关 键 词：病毒性肝炎 非甲-庚型肝炎 TTV感染 

分 类 号：R512.63[医药卫生—内科学]