血管内皮细胞粘附分子与心血管疾病  

作　　者：钱冠清[1] 

机构地区：[1]中国协和医科大学

出　　处：《基础医学与临床》1999年第3期6-11,共6页Basic and Clinical Medicine

摘　　要：缺血性心脑血．管疾病是在动脉粥样硬化（AS）的基础上发展而成，目前已认识到AS是慢性炎症过程，在AS形成早期，单核细胞粘附到活化内皮细胞，而后穿过内膜迁移到内膜下，分化成巨噬细胞，摄取氧化低密度脂蛋白而成泡沫细胞，在血管壁上形成脂肪条纹，巨噬细胞释放多种细...Adhesion of leukocyte to vascular endothelium is an important event in initiation of atherosclerotic lesion, ischemic reperfusion injury and vasculitis. Diverse risk factors associated with the initiation of atherosclerosis and cardiovascular disease induce the expression of cell adhesion molecules (CAM). which is a key regulatory factor in the control of leudocyte accumulation in lesions. Activation of the NF-κB and endothelial oxidantive stress may be a final common pathway for the induction of CAM gene activation. Recent insight into the mechanism by which leukocytes adhere to vascular endothelium might open new frontiers of molecular therapy to alleviate tissue damage in cardiovascular disease.

关 键 词：心血管疾病 血管内皮细胞 粘附分子 

分 类 号：R543[医药卫生—心血管疾病]