五配位阴离子型有机锡化合物[HNR_3][MeCy_2ClSnO_2CCH_2CO_2SnClCy_2Me]的合成及生物活性研究  

Synthesis and Biological Activities of Five-Coordinated Anionic Organotin(Ⅳ) Complexes[HNR_3][MeCy_2ClSnO_2CCH_2CO_2SnClCy_2Me]

作　　者：钟桂云[1] 孟宁[2] 陈昌炽[1] 孙丽娟[3] 谢庆兰[3] 

机构地区：[1]江门职业技术学院材料技术系,广东江门529090 [2]内蒙古大学图书馆,呼和浩特010021 [3]南开大学元素有机化学国家重点实验室,天津300071

出　　处：《内蒙古大学学报（自然科学版）》2010年第6期660-664,共5页Journal of Inner Mongolia University：Natural Science Edition

基　　金：国家自然科学基金资助项目(No.:20372035)

摘　　要：在有机胺的存在下,MeCy2SnCl与HOOCCH2COOH反应,得到了一系列的五配位阴离子型有机锡化合物,分子结构通式为:[Q][MeCy2ClSnO2CCH2CO2SnClCy2Me](Q=HNR3=H2NEt2(1),HNEt3(2),H2N(i-Pr)2(3)),并通过IR,1H NMR,元素分析对这些化合物进行了表征.测定了[H2N(i-Pr)2]2[MeCy2ClSnO2CCH2CO2SnClCy2Me](3)的晶体结构.结果表明,分子由一个二价阴离子和两个二异丙基胺阳离子组成.锡原子为变形的三角双锥结构,氧原子和氯原子处于竖直轴上.阴阳离子之间通过氢键(N-H…O,N-H…C)相连接,氮原子和氧原子及氮原子和氯原子之间的距离分别为2.798和3.189.测定了化合物的体外抗肿瘤活性和杀菌活性,结果表明该类化合物具有很强的体外抗肿瘤活性和杀菌活性.A series of new ionic organotin（IV）complexes with general formula[Q][MeCy2ClSnO2 CCH2CO2SnClCy2 Me] （Q = [ HNR3 ] - diethylammonium, triethylammonium, di-i-propylamrnonium）were synthesized by the reaction of malonie acid with methyldicyclohexylltin chloride in the presence of an organic base. These complexes have been characterized by elemental analyses,IR and i H NMR spectroscopies. The crystal structure of[H2N（i-Pr＇）2 ]2 [MeCy2ClSnO2CCH2CO2 SnCICy2 Me]was determined by X-ray crystallography. The structure consists of an dianion part and two di-i-propylamrnonium cation parts. The tin atom has a distorted cis-tbp geometry with three carbon atoms occupying the equatorial positions,and O atom and CI atom occupying the axial positions. The organotin anion and its counterion are connected through two hydrogen bonds between the N atom in the ammonium positions and the O atom,C1 atom of the carbonyl group with a N-O length of 2. 798 ,A and a N-C1 length of 3. 189 A. The activity of the compounds in vitro antitumor and bactericidal was tested,and the results showed that these compounds have a strong anti-tumor activity in vitro and bactericidal activity.

关 键 词：五配位有机锡化合物 离子型有机锡 晶体结构 

分 类 号：O621.3[理学—有机化学]