壳聚糖-海藻酸钠载药微球的缓释性能研究  

Drug-releasing Performance of Chitosan-Sodium Alginate Carrying Tetracycline Microsphere

作　　者：张琳琳[1] 涂姜磊[2] 徐静[1] 程莉萍[2] 张志斌[1] 陈世龙 

机构地区：[1]西南交通大学生命科学与工程学院,成都610031 [2]四川大学材料科学与工程学院,成都610065 [3]浙江凌志精细化工有限公司,杭州311305

出　　处：《材料导报》2010年第24期48-52,共5页Materials Reports

基　　金：国家自然科学基金资助项目(50573061);中央高校基本科研业务费专项资金(SWJTU09CX062;2010ZT09);成都尤耐复合材料有限公司资助项目(2009H01188)

摘　　要：采用滴球法制备了壳聚糖-海藻酸钠载四环素微球,考察了原料浓度配比、四环素投药量、添加戊二醛、滴球体积和壳聚糖分子量对微球的影响,并利用紫外分光光度计测试了载药微球在PBS溶液中1h、5h、1d、2d、5d、10d时的药物释放。结果表明,以8.5×104Da壳聚糖为原料、壳聚糖与海藻酸钠的浓度比为1.2∶1、未添加戊二醛、并用大针管滴定的实验组拥有比较理想的缓释性能和良好的生物相容性。The chitosan-sodium alginate carrying tetracycline microsphere is manufactured by using microsphere titration, the effects to the microsphere are studied by changing stuff concentration rate, carrying medicine dose, titration microsphere size,chitosan molecular weight and considering whether adding the glutaraldehyde. The drug-releasing performances of microsphere at 1h, 5h, 1d, 2d, 5d, 10d are explored with UV speetrophotometer. The results show that, when the raw material is 8. 5 ×10^6Da chitosan, the and without glutaraldehyde, the experiment group has the rate of chitosan and alginate concentration rate is 1.2 ： 1, satisfying release function and excellent biocompatibility.

关 键 词：壳聚糖海藻酸钠 四环素 缓释性能 

分 类 号：TQ441.41[化学工程—化学肥料工业]