丹参酮ⅡA对心血管保护作用的研究进展  

A review on Tanshinone Ⅱ A on the effect of cardiovascular protection

作　　者：倪惠君[1] 李秀才[1] 王友兰 朱震[3] 

机构地区：[1]青岛市黄岛区中医院,山东青岛266500 [2]青岛市药品检验所,山东青岛266071 [3]青岛医学院附属心血管病医院,山东青岛266071

出　　处：《中医临床研究》2010年第22期5-7,共3页Clinical Journal Of Chinese Medicine

摘　　要：目的：介绍近几年丹参酮ⅡA对心血管保护作用的研究进展,并探讨其可能的机制.方法：查阅和归纳总结近几年相关文献.结果：丹参酮ⅡA具有抗血小板聚焦作用,对心、肝,脑细胞具有保护作用;具有抗急性缺氧,保护心肌,防治冠心病作用;具有抑制血管平滑肌细胞增殖,抗动脉粥样硬化作用,对血管内皮细胞具有保护作用;具有抗心律失常作用;减轻心肌肥厚,保护心肌等多种心血管保护作用.结论：丹参酮ⅡA是中药丹参中一种非常有效的脂溶性成分,其药理作用显著,具有广阔的临床应用前景.Objective： Introduction in recent years, tanshinone Ⅱ A protective effect on cardiovascular research and to explore its possible mechanism. Methods： Search and summarize the literature in recent years. Result： Tanshinone Ⅱ A focus with anti-platelet effect on the heart, liver, brain cells play a protective role; With anti-acute hypoxia, myocardial protection, coronary heart disease prevention and control role; can inhibit vascular smooth muscle cell proliferation, anti-atherosclerosis effect. On vascular endothelial cells play a protective role; with antiarrhythmic effect; reduce cardiac hypertrophy, myocardial protection and other cardiovascular protection.Conclusion： Tanshinone ⅡA is the TCM Danshen in a very effective fat-soluble components, the significant pharmacological effects, is worth being clinically applied.

关 键 词：丹参酮ⅡA 心血管保护 丹参 

分 类 号：R28[医药卫生—中药学]