吲哚美辛载药量对宫内节育器基体材料性能及铜离子释放的影响  

Influence of drug loading of IMC on IUD materials and the release of cupric ions

作　　者：何泽文[1] 牟善松[1] 

机构地区：[1]暨南大学生命科学技术学院生物医学工程研究所,广东广州510632

出　　处：《暨南大学学报（自然科学与医学版）》2010年第4期378-380,共3页Journal of Jinan University(Natural Science & Medicine Edition)

基　　金：广东省科技计划项目基金项目(99B06704)

摘　　要：目的：评价不同吲哚美辛（IMC）药量对宫内节育器（IUD）基体材料物理机械性能及IUD内铜离子释放的影响。方法：采用电子万能试验机测量IUD基体材料的拉伸强度和撕裂强度;通过模拟人体宫腔内环境,采用电感耦合等离子体发射光谱仪测量铜离子的释放行为。结果：复合材料A、B、C、D和E组拉伸强度分别为（9.06±0.38）、（5.73±0.30）、（4.94±0.21）、（3.47±0.35）和（3.40±0.13）MPa;其撕裂强度分别为（38.12±0.77）、（29.44±0.36）、（25.76±0.99）、（24.57±0.89）和（21.48±1.39）N/mm。不同载药量Cu280-IUDs铜离子（Cu2＋）均呈现双相释放行为：早期快速释放与后期平稳释放。结论：IUD基体材料的拉伸强度和撕裂强度,随着IMC药量的增加而下降,IMC药量在8%~12%范围较合理。IMC含量对含铜IUD的铜离子释放无明显影响。Aim：To evaluate the influence of the loading of indomethacin（IMC） on mechanical properties of the intrauterine devices materials and the release of the copper ions. Methods： The tensile strength and tear strength of the intrauterine devices（IUDs） materials were measured by electronic universal testing machine.And inductively coupled plasma emission spectrometer（ICP-ES） was employed to determine the copper ions released from the matrix materials in the simulated uterine solutions.Results： The tensile strengths of the matrix materials of A,B,C,D and E were（9.06±0.38）,（5.73±0.30）,（4.94±0.21）,（3.47±0.35） and（3.40±0.13） MPa respectively.Accordingly,the tear strengths were（38.12±0.77）,（29.44±0.36）,（25.76±0.99）,（24.57±0.89） and（21.48±1.39） N/㎜.The release behaviors of Cu2＋ of Cu-IUDs with different drug loading were biphasic,which consisted of the initial burst release and the constant release.Conclusion：The tensile strength and tear strength of the matrix materials will decrease while the drug loading of IMC increases and the drug loading is just reasonable between 8% and 12%.The IMC amount in Cu-IUDs could not significantly influence the Cu2＋ release.

关 键 词：宫内节育器基体材料 吲哚美辛 铜离子 强度 释放行为 

分 类 号：R318.08[医药卫生—生物医学工程]