泌尿生殖道支原体感染及耐药性分析  

Analysis of mycoplasma infection rate and drug resistance in patients with genitourinary tract disease

作　　者：刘菊珍[1] 肖增璜[1] 叶仲毅[1] 付强[1] 李菊香[1] 

机构地区：[1]暨南大学附属第一医院临床检验中心,广东广州510630

出　　处：《暨南大学学报（自然科学与医学版）》2010年第4期418-420,共3页Journal of Jinan University(Natural Science & Medicine Edition)

基　　金：广东省医学科研基金项目(A2008341)

摘　　要：目的:监测泌尿生殖道解脲支原体(UU)、人型支原体(MH)感染发生率,分析其对抗生素的敏感性及耐药性,用以指导临床治疗。方法:采用支原体分离鉴别培养和药敏试剂盒,监测1998-2009年我院泌尿生殖道感染患者。结果:11 881例患者中检出支原体3 494例,阳性率为29.41%,其中UU阳性2 676例(22.52%)。UU+MH混合感染577例(4.86%),MH阳性241例(2.03%)。男性4 701例,阳性406例(3.41%);女性7180例,阳性3 088例(26%)。UU感染对环丙沙星耐药率最高为69.42%,其次是氧氟沙星为42.30%;UU与MH混合感染者对克拉霉素的耐药率最高为83.59%,其次是环丙沙星为82.81%;MH感染对克拉霉素的耐药率最高为88.89%,其次是罗红霉素为76.76%。结论:临床对泌尿生殖道UU感染可首选克拉霉素、交沙霉素;而对MH感染,UU、MH混合感染可首选交沙霉素、强力霉素。尽量参照药敏结果选择抗生素,定期监测支原体的耐药性变迁,规范用药。Aim： Monitoring of ureaplasma urealyticum（UU）,mycoplasma hominis（MH） infection rate,analysing their sensitivity and resistance to antibacterial drugs.Methods： Using culture and drug susceptibility of mycoplasma isolation identification kit.Results： Among 11,881 patients,3 494 patients were detected mycoplasma.The positivity is 29.41%,UU 2 676 cases（22.52%）,UU＋MH 577 cases（4.86%）,MH 241 cases（2.03%）.Detection rates for men and women were 3.41%,26%.UU infection to ciprofloxacin resistance reached 69.42% and to ofloxacin 42.30%,UU and MH mixed infection resistant rate to clarithromycin was 83.59%,to ciprofloxacin 82.81%.MH infection resistant to clarithromycin highest rate of 88.89%,to roxithromycin 76.76%.Conclusion：In the treatment UU infection of the urinary tract,clarithromycin and josamycin can be chosen firstly.While the MH infection,UU MH mixed infection,josamycin、doxycycline may be preferred.

关 键 词：解脲支原体 人型支原体 耐药性 

分 类 号：R691.3[医药卫生—泌尿科学]