雌激素替代治疗对绝经早期妇女颈内动脉及子宫动脉搏动指数的影响  

The Effects of Hormone Replacement Therapy on Pulsatility Index in Internal Carotid and Uterine Arteries in Early Postmenopausal Women

作　　者：徐锋[1] 王铁军[1] 杜星星[1] 

机构地区：[1]江苏省无锡市妇幼保健院妇产科,214002

出　　处：《中国全科医学》2010年第33期3757-3758,共2页Chinese General Practice

摘　　要：目的探讨绝经早期妇女应用雌孕激素联合方案替代治疗后对颈内动脉及子宫动脉搏动指数的影响。方法将48例有围绝经期症状的绝经早期患者随机分为两组:激素治疗组(25例)和安慰剂组(23例)。分别在治疗前和激素(1 mg/d戊酸雌二醇+1 mg/d醋酸炔诺酮)或安慰剂治疗4个月后行彩色多普勒超声测量颈内动脉及子宫动脉的搏动指数。结果治疗前后两组患者颈内动脉及子宫动脉的搏动指数比较,差异均无统计学意义(P>0.05)。两组患者治疗前后颈内动脉及子宫动脉搏动指数的比值比较,差异亦均无统计学意义(P>0.05)。结论激素替代治疗方案无增加绝经早期妇女血管阻力的副作用。对年轻的绝经早期妇女进行激素替代治疗并不增加脑血管疾病的发生风险。Objective To study whether hormone replacement therapy of estradiol valerate and norethisterone have any effect on the pulsatility index（PI） of the internal carotid and uterine arteries in early postmenopausal women.Methods A group of 48 healthy postmenopausal women with no history of hormone therapy（HT） were randomly divided into two groups： HT treatment group（n = 25） and placebo group（n = 23）.Doppler ultrasound test was used to measure the pulsatility index（PI） of internal carotid and uterine arteries before and 4months after the treatment.Results There was no significant difference in pulsatility index and pulsatility index ratio of the internal carotid and the uterine arteries 4 months after HT treatment（P 0.05）.Conclusion This HT regimen showed no significant negative impact on vascular resistance in early postmenopausal women.Results are compatible with the updated recommendations on HT stating that there is little cerebrovascular risk when HT is initiated within a few years of the menopause.

关 键 词：雌激素替代疗法 绝经期 搏动指数 颈内动脉 

分 类 号：R271.11[医药卫生—中医妇科学]