肿瘤靶区呼吸运动位移误差补偿系统模型的研究  

The Model Development for Compensating the Displacement Error of Tumor Target Breathing Movement

作　　者：徐子海[1] 伍锐[2] 朱超华[2] 黄志业[2] 

机构地区：[1]解放军303医院放疗中心,南宁530021 [2]南方医科大学生物医学工程学院,广州510515

出　　处：《生物医学工程研究》2010年第2期133-135,138,共4页Journal Of Biomedical Engineering Research

基　　金：广东省自然科学基金资助项目(06024583);广东省科技计划项目(2007B01040056)

摘　　要：在肿瘤精确放射治疗过程中,减少照射靶区呼吸运动造成相对于静止照射野的照射位移误差量。我们采用步进电机驱动的机电一体化系统,以控制一块叠放在原加速器治疗床上的可移动平台,在治疗过程中的每一时刻,使之能够在二维冠状平面带动患者的体位,实现对肿瘤靶区实施呼吸运动造成位移的实时反向跟踪运动。通过CT扫描和图像重建的算法,可以检测出在使用运动补偿系统前后,患者肿瘤靶区在冠状平面上呼吸运动位移量的大小,经过对比后发现,后者的位移误差量确实小于前者。使用肿瘤靶区呼吸位移误差补偿系统,能够比较有效地缩减靶区的呼吸运动范围,在肿瘤精确放疗计划的设计过程中,对缩小计划靶区(PTV)范围以提高肿瘤治疗增益比(TCP)发挥了重要的作用。To reduce displacement error of tumor target breathing movement relative to the radiation field in precise radiotherapy for tumor.The mechatronics system drived by stepper motor was adopted to control a working couch which is put onto the existed treatment couch,to make the patients＇ body moving inversely to the tumor target in coronal plane at any time during the treatment period.Through CT scanning and algorithm of image construction,we could obtain the displacement signal of tumor target breathing movement in coronal plane before and after utilizing the error compensating system.Through contrast we could find that after using the system,the displacement of tumor target decrease.Adopting the compensating system can effectively reduce the breathing movement region of the tumor target,so this method can play a very important role in reducing the PTV in the course of designing the treatment plan in radiotherapy.

关 键 词：精确放射治疗 呼吸运动 步进电机 机电一体化 反向跟踪 图像重建 位移误差 肿瘤靶区 补偿系统 

分 类 号：R318[医药卫生—生物医学工程]