芹菜素对大鼠阿霉素性急性心肌损伤的影响  

Effect of apigenin on the adriamycin-induced acute myocardial injury in rat

作　　者：王仙[1] 于肯明[2] 

机构地区：[1]山西医科大学研究生院,030001 [2]大同大学医学院

出　　处：《中国现代药物应用》2010年第23期4-5,共2页Chinese Journal of Modern Drug Application

摘　　要：目的观察芹菜素(Apigenin,API)对大鼠阿霉素(Adriamycin,ADR)性急性心肌损伤的影响。方法将雄性SD大鼠40只随机分为5组:对照组、ADR组、ADR+API(L)组、ADR+API(M)组、ADR+API(H)组。光镜下进行心肌组织病理形态学的观察,并用TUNEL法检测凋亡的心肌细胞,ELISA法检测血清心肌酶(CK-MB)的改变。结果 ADR组大鼠光镜下的心肌损伤情况明显重于其他各组,CK-MB、AI值升高(P<0.01);ADR+API组大鼠上述指标的变化减轻,尤以ADR+API(M)、ADR+API(H)组变化显著(P<0.01)。结论芹菜素对大鼠阿霉素性急性心肌损伤具有一定的保护作用。Objective To observe the effect of apigenin（API） on the adriamycin -induced acute cardiomyopathy.Methods Male SD rats （n=40） were randomly divided into five groups：Control,ADR,ADR＋API（L）, ADR＋API（M）,ADR＋API（H）.The morphology of cardiomyocyte,apoptosis index（AI）and CK-MB were detected.Results The cardiomyopathy of ADR Group was much severer than other groups, the values of CK-MB、AI in the ADR Group increased（P〈0.01）and the values of above-mentioned indexes in ADR＋API Groups decreased,especially the API（M）、API（H） Groups decreased significantly（P〈0.01）.Conclusion Apigenin could protect the rats against the acute adriamycin-induced cardiomyopathy.

关 键 词：芹菜素 阿霉素 细胞凋亡 CK-MB 

分 类 号：R285.5[医药卫生—中药学]