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作 者:孙爱励[1] 胡晓东[1] 吴待英[1] 王兆军[1]
机构地区:[1]河北省医学科学院实验医学研究所
出 处:《高血压杂志》1999年第1期30-32,共3页Chinese Journal of Hypertension
摘 要:目的探讨伴Ⅱ型糖尿病的高血压(EH+DM)患者胰岛素抵抗(IR)与红细胞膜胰岛素受体之间关系。方法原发性高血压(EH)患者18例,Ⅱ型糖尿病(DM)患者26例,EH+DM患者21例,正常人(NT)24例作为对照。取晨空腹肘静脉血分离血浆和红细胞,检测血糖(BG)、血胰岛素(INS)及红细胞膜胰岛素受体(INSR)数目和亲和力。结果与NT组比较,EH组BG水平(mmol/L)在正常范围(6.1±0.7vs5.1±0.9,P>0.05),INS水平(mU/L)明显升高(19.5±11.4vs13.5±5.2,P<0.01)口服葡萄糖耐量试验中BG曲线下面积(mmol/L·h-1)明显增大(21.7±4.2vs18.4±3.4,P<0.01),INS曲线下面积(mmol/L·h-1)明显增大(179.8±73.1vs110.0±42.5,P<0.001)。高亲和力INSR数目明显减少(P<0.05)。DM组和EH+DM组的BG和INS水平及BG曲线下面积明显高于EH组(P<0.01),而后者INS曲线下面积与EH组无显著性差别,高亲和力INSR数目较EH组明显减少(P<0.001)。结论IR不仅是Ⅱ糖尿病发病的重?Aim\ To investigate the relationship between insulin resistance(IR)and insulin receptors (INSR)in patients with essential hypertension(EH)associated with Ⅱ type diabetes mellitus (DM).\ Methods\ Plasma glucose (BG) and insulin (INS)before and during the oral glucose tolerance test (OGTT), and erythrocyte INSR were determined in 18 patients with EH,26 patients with DM, 21 patients with EH+DM,and 24 normotensive control subjects (NT).\ Results\ Plasma BG levels in EH was within the normal range,INS level is significantly increased. The area under the curve (AUC) of OGTT is in the upper limited value of normal range. The AUC of INS in OGTT is markedly increased, and the number of INSR with high affinity is significantly decreased in EH group. Plasma BG and INS levels,and AUC of plasma BG are significantly higher in groups of DM and EH+DM. The numbers of INSR with high affinity are significantly decreased than those in EH group( P <0.01).\ Conclusions\ IR is not only the crucial pathogenesis mechanism for diabetes mellitus,it seems to be a main factor for promoting the development of hypertension. Decreased INSR number in erythocyte has been shown to be associated with IR.
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