卡托普利对高血压冠状动脉壁肥厚和储备力下降的预防作用  

Effects of Captopril on Hypertrophy and Reducing Reserve of Coronary Arteries in Hypertension

作　　者：章建梁[1,2,3] 章同华[1,2,3] 秦永文 杨向群[1,2,3] 沙继宏 张国元[1,2,3] 陈思聪 

机构地区：[1]第二军医大学 [2]长海医院 [3]长征医院心内科

出　　处：《高血压杂志》1999年第1期39-42,共4页Chinese Journal of Hypertension

摘　　要：目的研究卡托普利对高血压冠状动脉壁肥厚和储备力下降的预防作用。方法４ｗ大鼠设３组：分别为自发性高血压大鼠（ＳＨＲ）组、ＳＨＲ口服卡托普利组（ＳＨＲ＋Ｃ）和正常血压大鼠（ＷＫＹ）组，饲养１２ｗ。结果ＳＨＲ＋Ｃ组较ＳＨＲ组，收缩压、冠状动脉壁横截面积、横截面积与内径比及中层血管平滑肌细胞宽度显著下降，最大冠状动脉流量增加，与ＷＫＹ组无显著差异。结论卡托普利能完全预防ＳＨＲ冠状动脉壁肥厚和储备力下降。Objective\ To study effects of captopril on left ventricular hypertrophy and the reduced reserve of coronary arteries in hypertension.\ Methods\ 4 week old rats were divided into three groups: spontaneously hypertensive rats(SHR) group, SHR+captopril(SHR+C,40mg/kg qd) group and normtensive Wistar Kyoto rats(WKY) group. Systolic blood pressure(SBP) was measured. Maximal coronary flow(MCF) was measured by using an isolated perfused rat heart model. Cross sectional area(CSA) and CSA/lumen diameter(CSA/LD) of coronary arteries were analysed by computer, and morphology of vascular smooth muscle cells(VSMC) of the left anterior descending coronary artery was investigate by electromicroscopy.\ Results\ Compared with SHR group,SBP, CSA, CSA/LD and the size of VSMC reduced significantly in SHR+C group. In addition, MCF increased greatly in SHR+C group(34.9±3.24 ml·min -1 ·g -1 ) compared with SHR group(23.3±1.99 ml·min -1 ·g -1 ).\ Conclusion\ Captopril could effectively prevent the hypertrophy and improve the reducing reserve of coronary arteries in SHR.

关 键 词：冠状动脉 高血压 卡托普利 动脉壁肥厚 储备力 

分 类 号：R544.105[医药卫生—心血管疾病]