原发性高血压遗传模式研究  

Genetic Model in Essential Hypertension

作　　者：公茂莲[1,2,3] 张红叶 扬军 李莹[1,2,3] 池建超 黄诚群[1,2,3] 郭敏 田野 池丽珠 王颖玲 倪鹏生 沈福民 

机构地区：[1]北京阜外医院心血管病研究所,中国医学科学院中国协和医科大学阜外心血管病研究所阜外心血管病医院流研室 [2]上海医科大学流行病教研室 [3]北京石景山慢性病防治所

出　　处：《高血压杂志》1999年第1期66-69,共4页Chinese Journal of Hypertension

基　　金：国家自然科学基金;中国医学科学院基金

摘　　要：目的为分析原发性高血压的遗传模式及其环境协变量的作用。方法我们对３９个原发性高血压家系共２９６人用Ｐｅｎｒｏｓｅ＇ｓ法估计一般遗传模式，用Ｆａｌｃｏｎｅｒ法估算遗传度，并用ＳＡＧＥ软件拟合Ａ型回归Ｌｏｇｉｓｔｉｃ模型，进行复合分离分析。结果原发性高血压为多基因遗传，遗传度为７０．００％±１１．８６％；接受隐性模型，主基因模型处于临界状态，虽在０．０５界值上拒绝，但不能否认可能是主基因模型中存在隐性孟德尔遗传效应，拒绝单纯环境模型、非传递模型、显性模型、共显性模型，；协变量体重指数、血浆总胆固醇、尿酸均增加患病危险。结论认为原发性高血压为多因子遗传疾病。S\ Aim To investigate the genetic model of essential hypertension(EH).\ Methods\ Genetic model of essential hypertension(EH) and effect of environmental factors were analysed in 39 pedigrees. The common genetic model of EH was analysed with Penrose's method and the multiple gene model was accepted; the heritability for EH was 70.00±11.86%.\ Results\ Cosegregation analysis showed that the estimation of recessive genetic model was accepted, major gene model shouldn't be rejected, because the estimation value of it was borderline; Body mass index, plasma total cholesterol and uric acid increased the risk of EH.\ Conclusion\ EH was multiple variant disease, and there existed interaction of genetic and environmental factors.

关 键 词：高血压 遗传模式 环境因素 

分 类 号：R544.101[医药卫生—心血管疾病]