糖化血红蛋白和血清铁蛋白的相关性研究  

Study on the relationship between serum ferritin leveland Glycosylated hemoglobin in type 2 diabetes mellitus

作　　者：卢颖[1] 张忆敬 薄建华[1] 李聪龙[1] 苏美玲[1] 管秀静[1] 张淑英[1] 

机构地区：[1]内蒙古包头市第八医院,014040

出　　处：《中国医学创新》2010年第34期15-17,共3页Medical Innovation of China

摘　　要：目的探讨2型糖尿病患者血清铁蛋白(SF)和糖化血红蛋白(HbA1c)等的临床相关性,为临床合理防治2型糖尿病提供又一新的途径。方法将75例2型糖尿病患者,按血清铁蛋白(SF)浓度的50百分位点分为:低SF组和高SF组,比较他们体质量指数(BMI)、糖化血红蛋白(HbA1c)、血糖(BG)、血脂谱、空腹胰岛素(FINS)等指标,同时用HOMA公式计算出胰岛素抵抗指数(HOMAIR)和胰岛β细胞功能(HOMAβC)进行分析。结果高SF组的BMI、FBG、PBG、HbA1c、CHO、TG、LPα均明显高于低SF组(P<0.01);高SF组的LDLC、APOB、HOMAIR也高于低SF组(P<0.05);而FE,HDLC、APOA、FINS、HOMAβC无统计学差异。各项指标相关分析中,血清SF和HbA1c、BMI、FBG、TG、CHO呈高度正相关;血清SF和HOMAIR呈中等程度相关;血清SF和HOMAβC呈中等程度负相关。结论血清铁蛋白与2型糖尿病密切相关,临床表现在糖化血红蛋白,空腹和餐后血糖,血脂谱,胰岛素抵抗、β细胞功能等方面,血清铁蛋白浓度增加伴随着糖尿病危险因素的增高。所以血清铁蛋白可以协助观察后者血糖控制情况甚至协助诊断,亦可作为并发症风险的预测因子,可以考虑做为2型糖尿病防治的新思路。Objective To investigate the relationship between serum ferritin level（SF） and Glycosylated hemoglobin （ HbA1 c） in type 2 diabetes mellitus. Methods Seventy - five patients with type 2 diabetes were stratified by the 50th percentile serum ferritin, as lower SF group and higher SF group. HbA1 c , body mass index （BMI） serum lipid, blood glucose, fasting blood insulin were analysed. Insulin resistant index （HOMAIR） and 13 -cell function（HOMAβ -cell） was calculated by HOMA formula. Results The level of HbAlc, fasting blood glucose, postprandialblood lucose , cholesterol , triglycerides and lipoproteinαwere obviously increased in patients with higer SF than that in patients with lower SF（P 〈0. 01 ）. The level of Low - density lipoprotein cholesterol, apolipoprotein B, HOMAIR also increased in patients with higer SF than that in patients with lower SF（P 〈 0. 05 ）. But there were no significant difference between the two groups in serum iron, high - density lipo- protein cholesterol, apolipoprotein A,fasting plasma insulin and ttOMA13 -cell. The SF was significant positively correlated with HbA1 c, BMI, fasting blood glucose, triglycerides and cholesterol levels. The SF was moderate positively correlated with HOMAIR. But it was moderate ,negatively correlated with HOMAβ - cell. Conclusion Serum ferritin is closely related with type 2 diabetes mellitus, including the climical maifestation such as HbAI c , blood glucose , serum lipid, insulin resistance and β -cell function. Elevated serum ferritin concentration was associated with an increased risk of diabetes. Therefore, serum ferritin can predicte type 2 diabetes mellitus and its complications, and used as an important target of prevention and therapy for type 2 diabetes. It will be helpful to monitoring blood glucose and assistance diagnosis. The SF also be used as predictive factors to complications of type 2 diabetes mellitus, future new thinking to control it.

关 键 词：血清铁蛋白 糖化血红蛋白 血脂谱 胰岛素抵抗 β细胞功能指数 

分 类 号：R587.1[医药卫生—内分泌]