KA8肽的合成及其对五肽胃泌素刺激大鼠胃液分泌的抑制作用  

Synthesis of KA8 Peptide and its Inhibitory Effect on Pentagastric-Stimulated Gastric Acid Secretion in Rats

作　　者：张家瑾[1] 张绍东[1] 张辉[1] 关玲玲[1] 盛树力[1] 梁丕霞[2] 

机构地区：[1]北京市神经外科研究所 [2]北京天坛医院

出　　处：《首都医学院学报》1990年第4期299-301,共3页

摘　　要：胃酸分泌调节肽是一个37肽。1-29肽段即为胰高糖素,而C-端8肽称为KA8。用固相法合成了此八肽,并观察了它的生物活性。实验结果表明五肽胃泌素能明显刺激胃酸分泌,但这种刺激作用可被预先给予的KA8所抑制,因此,KA8可能是一种胃酸分泌调节肽。KA8 peptide is a c-terminal octapeptide 30~37 of oxyntomodulin 1~37. Oxyntomodulin 1~29 is a glucagon, which can increasa the concentration of blood glucose, but oxyntomodulin has a obvious inhibition of gastrie acid secretion. In order to understand the KA8 biologieal activity, we have synthesized KA8 and injected to rats before administration of pentagastrin. The experiment showed that pentagastrin stimulated definitively gastric acid secretion. However, KA8 could eliminated the pentagastrin induced gastric acid secretion. Our result reveals that KA8 plaies probably a important role in the regulation of gastric acid secretion.

关 键 词：KA8肽 五肽胃泌素 

分 类 号：R965[医药卫生—药理学]