KA8肽抑制TRH和冷束缚引起的胃酸分泌增加  

KA8 Inhibite Gastric Acid Secretion Induced by Cold-restraint Stress and Intracisteral TRH in Rat

作　　者：张绍东[1] 关玲玲[1] 梁丕霞[2] 王霄虹[1] 张家瑾[1] 杨昭徐[2] 张辉[1] 陈雁江[1] 盛树力[1] 

机构地区：[1]北京市神经外科研究所 [2]北京天坛医院

出　　处：《首都医学院学报》1990年第4期302-304,共3页

摘　　要：KA8是oxyntomodulin和glicentin的C端八肽(30-37)。KA8可以抑制胃酸分泌。我们设计了两个实验,证明KA8可以抑制冷束缚和TRH刺激引起的胃酸分泌,血中胃泌素水平无明显变化。这说明KA8不是通过抑制胃泌素而起作用的。KA8 is a C-terminal octapeptide (30-37) of oxyntomodulin and glicentin. KA8 could inhibite gastric secrection. But it is not clear if KA8 is able to inhibite gastric secrection induced by cold-restraint and TRH administration in intracerebroventricle. We designed two experiments. All the rats were fasted for 24 h before experiment. The rats with light ether anaesthesia were undertook the operation of pylorus and cardia ligation. After the rats remained consciousness, the rats were divided into two groups. One Was injected by iv KA8 (60μg/kg), another was gaven NS as control, then the rats were sxposed 4 C enviroment for 2 hours. In the second experiment, the rats were implanted with tube in cerebro-ventricle before one week. The rats were administrated TRH (60μg/kg) through the tube and divided into two groups. One was injected by iv KA8, another Was received NS as a control. Each rat was placed in separated cage for 4 hours. All rats were decapitated and plasmas were stored in -20℃ for gastrin determination. The resoults shown that KA8 could significantly inhibited gastric secretion not only for rats exposed to cold, but also for TRH icy administration. But KA8 was not able to infulence the plasma concentration of pentogastrin. It suggest that KA8 inhibit gastric secretion but the biologica activity of KA8 is not associated with pentogastrin.

关 键 词：KA8肽 胃酸调节肽 胃酸分泌 

分 类 号：R965[医药卫生—药理学]