内皮素鞘内注射后的脊髓形态学观察  

The Morphological Alteration of the Spinal Cord following Intrathecal Injection Endothelin in the Rat

作　　者：周力[1] 罗麟[1] 王霄虹 陈雁江 盛树力 

机构地区：[1]北京市神经外科研究所

出　　处：《首都医学院学报》1990年第4期251-254,共4页

摘　　要：对18只大鼠进行内皮素脊髓鞘内注射,观察及记录大鼠后肢功能状态,并将18只大鼠分为3个不同的时间处死,进行病理形态学观察。结果表明:3组均表现缺血缺氧病理改变。2及4h实验组病变重于30min实验组。脊髓下胸段、腰段病变重于颈段及骶尾段。同时发现,大鼠后肢的功能状态与其脊髓相应的病理形态学变化不呈正比。Endothelin was injected into subarachnoid space of spinal cord in eighteen rats. The functional state of the animals hindlimbs was observed and recorded. After half an hour, two hours or four hours the rats were killed. Pathologicaly the spinal cord revealed ischemic and hypoxic changes. The changes at two hours and four hours were more severe than that of half an hour. The changes of thoracic and lumbar segment of the spinal cords were more severe than that of the cervices and sacra. We found that the founctional state of rat hindlimbs was not in proportion to the morphological changes of corresponding spinal cord.

关 键 词：肉皮素 鞘内注射 缺血缺氧 

分 类 号：R972.9[医药卫生—药品]