失水山梨醇脂肪酸酯-聚乙二醇嫁接的聚乙烯醇化磁性药物载体的制备及应用  

Preparation and Application of Polyvinyl Alcohol-Magnetic Drug Carrier Modified by Sorbitan Monooleate-Polyethylene Glycol

作　　者：金谷[1] 姚剑侠[1] 姚奇志[1] 

机构地区：[1]中国科学技术大学化学系,合肥230026

出　　处：《分析化学》2010年第5期723-726,共4页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金(No.29405038)资助项目

摘　　要：通过丁二酸酐将失水山梨醇脂肪酸酯(Span80)和聚乙二醇(PEG400)联接在一起,合成了一种新的非离子表面活性剂。然后将其嫁接在聚乙烯醇(PVA)化的Fe3O4磁性粒子上,合成了一种新型靶向药物载体。这种载体兼备了Span80/PEG400类脂囊泡和磁性材料的特点,具有良好的稳定性和靶向作用。将这种新型载体用于两性霉素的包封,包封率可达96.6%,且方法简便。实验过程中采用了FTIR,NMR,XRD和TEM等多种手段进行表征。A new non-ionic surfactant was synthesized by using Span 80 and polyethylene glycol 400（PEG 400） in the presence of succinic anhydride. Then, the surfactant was grafted onto PVA-coated Fe3O4 magnetic nanoparticles. As a result, a kind of new drug carrier with magnetic targeting was prepared. Several instruments, such as FTIR, NMR, XRD, TEM were used to characterized the carrier. Finally, the targeting carrier was applied to envelop the amphotericin. The envelopment was up to 96.6%, and the method was handy.

关 键 词：失水山梨醇脂肪酸酯 聚乙二醇 聚乙烯醇 药物载体 磁性粒子 

分 类 号：TQ460.4[化学工程—制药化工]