参麦注射液对肠缺血再灌注肠、肺损伤的保护作用  

Protective effects of shenmai injection on injury of intestine and lung induced by intestinal ischemia/reperfusion(I/R)

作　　者：王艳蕾[1] 夏冰杰[2] 刘晓荣[3] 蔡庆艳[1] 崔国金[1] 景友玲[1] 田华[4] 刘敏[5] 

机构地区：[1]华北煤炭医学院基础部生理学教研室 [2]华北煤炭医学院附属医院神经外科,河北唐山063000 [3]唐山市丰润区第二人民医院 [4]唐山市丰润区人民医院 [5]唐山市中医院

出　　处：《华北煤炭医学院学报》2010年第6期765-767,共3页Journal of North China Coal Medical College

基　　金：河北省唐山市科学技术研究与发展计划课题(编号:09130202A-3-7)

摘　　要：①目的探讨参麦注射液对肠缺血再灌注肠、肺损伤的保护作用及其机制。②方法采用夹闭肠系膜上动脉方法复制大鼠肠缺血再灌注(I/R)损伤模型,观察参麦注射液对血浆和肠组织超氧化物歧化酶(SOD)、丙二醛(MDA)、二胺氧化酶(DAO)以及肺组织SOD、MDA的影响,同时观察肠、肺组织水肿和病理损害。③结果参麦注射液可显著改善肠、肺组织损伤,降低肠及肺组织湿/干比值、MDA含量、血浆DAO和MDA水平(P<0.01),同时升高血浆、肠及肺组织SOD以及肠组织DAO水平(P<0.01)。④结论参麦注射液可能通过清除氧自由基,对抗脂质过氧化损伤,对肠I/R后肠、肺组织损伤起到保护作用。Objective To investigate the protective effects of Shenmai injection on the injury of intestine and lung induced by intestinal ischemia/repeffusion（I/R） and explore its possible mechanism. Methods Rat model of intestinal I/R injury was es- tabished with clamping of the superior mesenteric artery for 60 rain , then clamping was relieved for 60 rain. The effects of Shenmai injection on Superoxide dismutase （SOD）, malondialdehyde （MDA） , diamine oxidase （DA0） in serum and intestine tissue and SOD,MDA in lung tissue were observed, as well as tissue edema and pathological changes were measured. Results Shenmai injec- tion could obviously lessen tissue injury, decrease wet/dry weight ratio and the level of MDA in intestine and lung tissue and the level of DAO, MDA in plasma （ P 〈 0.01 ） , and markedly increase SOD level in plasma, intestine and lung and DAO level in in- testine （ P 〈 0.01 ）. Conclusion Shenmai injection can protect the injury of intestine and lung induced by intestinal ischemia/ reperfusion（I/R） , which may be mediated by geting rid of free radicals and inhibiting lipid peroxidation.

关 键 词：参麦注射液 缺血再灌注 脂质过氧化 肠 肺 

分 类 号：R563.8[医药卫生—呼吸系统]