二苯并-18-冠-6的超声合成及改进  

Optimization of Ultrasonic Synthesis of Dibenzo-18-crown-6

作　　者：刘学文[1] 朱沈[1] 马鸿飞[1] 康学军[2] 韩国志[2] 

机构地区：[1]南京工业大学理学院应用化学系,江苏南京210009 [2]南京东南大学学习中心,江苏南京210096

出　　处：《化工时刊》2010年第11期27-29,共3页Chemical Industry Times

基　　金：苏州市应用基础研究项目(No.SYJG0912)资助

摘　　要：以邻苯二酚,二氯乙基醚为原料,二甲亚砜为溶剂,氢氧化钾为催化剂及模板剂,采用超声法合成了二苯并-18-冠-6。通过IR和1H NMR对产物结构了进行表征。并对反应温度和时间进行了优化。针对传统超声方法产率较低的问题,添加了2,6-二叔丁基-4-甲基苯酚作为抗氧剂对反应进行了改进,结果表明,添加抗氧化剂之后,产率从17%增加到46%。Using o-dihydroxybenzene,2,2’-dichloroacetyl ether as starting materials,dimethyl sulfoxide as solvent and potassium hydroxide as catalyst and template,dibenzo-18-crown-6 was synthesized by ultrasonic synthetic method.The product was characterized by IR and 1H NMR,and reaction condition was optimized for temperature and reaction time.Because of low yield in traditional ultrasonic methods,2,6-Di-tert-butyl-4-methylphenol was added as antioxidant.The result indicated that the yield increased from 17% to 46%.

关 键 词：超声合成 邻苯二酚 二氯乙基醚 二苯并-18-冠-6 

分 类 号：TQ241[化学工程—有机化工]