铜中毒对SD大鼠肝的影响研究  

Effects of Copper Poisoning on Liver in SD Rats

作　　者：陈通克[1] 管敏强[1] 李翔[1] 王一龙[1] 李安乐[1] 陈锡文[1] 

机构地区：[1]温州医学院实验动物中心,浙江温州325035

出　　处：《广东微量元素科学》2010年第10期17-21,共5页Trace Elements Science

摘　　要：将36只雄性大鼠80-100 g随机分为3组,分别喂以对照日粮（Cu质量分数13.15mg/kg）和高铜日粮（Cu质量分数650、850 mg/kg）,实验期为9周,进行了铜中毒对大鼠肝脏影响的病理学研究。结果表明,与对照组比较,高铜Ⅰ、Ⅱ组大鼠肝脏出现不同程度的病理损害;大鼠肝脏脏器系数有增高趋势,但差异无显著（P〉0.05）。同时,乳酸脱氢酶、谷草转氨酶活性显著升高（P〈0.01）,血清铜含量上升,SOD含量下降。提示日粮铜质量分数650~850 mg/kg即可引起大鼠肝脏的病理损伤,功能降低。Thirty six SD male rats weighted 80~100 g were randolnly divided into three grougs,and fed on diets as follows：control（Cu 13.15 mg/kg）,copper toxic I（Cu 650 mg/kg）and copper toxic Ⅱ（Cu 850 mg/kg）for studying effects of copper toxicity on liver in rats by the methods of experimental pathology for nine weeks for exploring the effect of high diet copper on some liver parameters.The result showed that lesions were appeared in high copper groupsⅠ and Ⅱ when compared those with control group.There were increased the liver of rats coefficien in high copper groupsⅠ and Ⅱ（P0.05）.Also,LDH,GOT and liver copper contents in high copper groupsⅠand Ⅱ were much higher in the control group（P0.01）.The control group SOD activities were higher in high copper groupⅠand Ⅱ the dietary copper in range of 650~850 mg/kg caused pathological injures in liver of SD rats.

关 键 词：铜中毒 肝脏 生化指标 大鼠 

分 类 号：R595.2[医药卫生—内科学]