肽基纳米材料及其应用  

Peptide Based Nanomaterials and Their Technological Applications

作　　者：黄仁亮[1] 齐崴[1,2] 姜楠[1] 苏荣欣[1,2] 何志敏[1,2] 

机构地区：[1]天津大学化工学院化学工程研究所,天津300072 [2]天津大学化学工程联合国家重点实验室,天津300072

出　　处：《化学进展》2010年第12期2328-2337,共10页Progress in Chemistry

基　　金：国家自然科学基金项目(No.20976125;20806057;31071509);天津市自然科学基金项目(No.10JCYBJC05100);教育部科学技术研究计划重点项目(No.108031);新世纪优秀人才支持计划项目(No.NCET-08-0386);国家高技术发展计划(863)项目(No.2008AA10Z318);高等学校学科创新引智计划(111计划)项目(No.B06006)资助

摘　　要：近年来,肽类超分子自组装合成纳米材料受到了广泛研究和关注,已成为纳米材料科学研究的前沿领域之一。肽基纳米材料因其良好的生物相容性以及结构和功能的多样性,在材料学、组织工程、生物工程及药物传递等方面展示出巨大的应用潜力。本文综述了肽类自组装纳米材料制备的最新研究进展,重点介绍了疏水性二肽、类表面活性剂多肽、Aβ多肽片段、烷基链修饰多肽等通过非共价键作用自组装形成的不同结构的纳米材料,包括纳米管、纳米纤维、纳米囊/球、纳米水凝胶等;同时,介绍了多肽自组装机理模型及其分子动力学模拟方面取得的研究成果;最后总结了肽基纳米材料在金属/半导体材料、生物传感器、组织修复材料及药物传递等领域的应用现状及今后重点研究的方向。The self-assembled peptide nanomaterials have been the focus of considerable research in recent years.Due to their good biocompatibility and the structure diversity,these materials are extremely attractive as building blocks for various applications such as material science,tissue engineering,bioengineering,and drug delivery.Firstly,this paper reviews the recent research concerning the self-assembly of peptides and their derivates into nanomaterials,including hydrophobic dipeptides,surfactant-like peptides,amyloid peptide fragments,and peptide-amphiphiles.Through the molecular self-assembling,these peptide molecules are assembled into various nanometer-scale structures and then further orgnaized to form nanotuber,nanofiber,nanovesicle,nanosphere and nanohydrogel.Meanwhile,the mechanism for the fomation of peptide assemblies and molecular dynamics simulation of the peptide self-asssembly are discussed.Finally,we introduces the application progress of the peptide-based nanomaterials,including the templates for the fabrication of metal /semiconductor materials,elements in biosensors,scaffolds for tissue engineering and regeneration,and carriers for drug delivery.

关 键 词：肽 自组装 纳米材料 生物传感器 药物传递 生物纳米技术 

分 类 号：O629.7[理学—有机化学] TB322[理学—化学]