乙型肝炎病毒宫内感染的流行病学研究  

Epidemiological study on intrauterine HBV infection

作　　者：王芳[1] 张海涛[2] 乔云波[3] 于广福[1] 李晓霞[1] 于爱莲[1] 

机构地区：[1]泰山医学院病原学教研室,山东泰安271000 [2]泰安市妇幼保健院 [3]济南市妇幼保健院,山东济南251001

出　　处：《中国病原生物学杂志》2010年第11期813-814,833,共3页Journal of Pathogen Biology

基　　金：山东省计生委资助项目(No.2006-6)

摘　　要：目的了解目前乙型肝炎病毒（HBV）宫内感染情况,评价孕晚期注射HBIG预防HBV宫内感染效果。方法选取2006年10月~2008年1月在济南市妇幼保健院住院的符合纳入标准的318名血清HBsAg阳性孕妇及其分娩的324名新生儿进行HBV感染流行病学调查。结果 HBsAg阳性孕妇分娩的新生儿HBV宫内感染率为17.59%（57/324）,其中孕晚期注射HBIG的HBsAg阳性孕妇分娩的新生儿HBV宫内感染率为9.76%（16/164）,孕晚期未注射HBIG的HBsAg阳性孕妇分娩的新生儿宫内感染率为25.63%（41/160）,差异有统计学意义（χ2=14.07,P〈0.01）。结论孕晚期注射HBIG能有效阻断HBV宫内感染。Objective To observe the rate of intrauterine infection with hepatitis B virus and evaluate the efficacy of injection of HBIG.Methods An epidemiological investigation was conducted with mothers（318） positive for hepatitis B surface antigen（HBsAg） and their newborns（324） at Jinan Maternal and Child Health Hospital.Results The rate of intrauterine infection with hepatitis B virus was 17.59%（57/324）.The rate of intrauterine infection among newborns whose mothers were injected with HBIG was 9.76%（16/164）;the rate of intrauterine infection among newborns whose mothers who were not injected with HBIG was 25.63%（41/160）.The difference between the two groups was significant.Conclusion Injection of HBIG had a role in protecting newborns from HBV intrauterine infection.

关 键 词：乙肝病毒 宫内感染 新生儿 

分 类 号：R373.21[医药卫生—病原生物学]