胺碘酮治疗充血性心力衰竭并快速型心律失常的疗效和安全性研究  

Efficacy and Safety of Amiodarone in the Treatment of Tachyarrhythmia with Congestive Heart Failure

作　　者：朱鹏程[1] 黄楚泉 林振发[1] 

机构地区：[1]饶平县华侨医院心内科,广东饶平515700

出　　处：《医学综述》2010年第22期3497-3499,共3页Medical Recapitulate

摘　　要：目的观察胺碘酮治疗慢性充血性心力衰竭并快速型心律失常的疗效和安全性。方法慢性心力衰竭合并快速型心律失常患者120例随机分为观察组和治疗组各60例,入院后均接受正规抗心力衰竭治疗,在此基础上观察组口服胺碘酮,对照组口服心律平。观察两组患者的临床疗效。结果治疗4周后,观察组总有效率为88.3%,对照组为68.3%。两组临床疗效及室上性心律失常、室性心律失常改善情况间差异有统计学意义(P<0.05)。治疗期间无一例因使用胺碘酮致心功能恶化。结论胺碘酮治疗充血性心力衰竭合并快速型心律失常的疗效和安全性优于心律平,可作为首选的抗心律失常药。Objective To observe the efficacy and safety of amiodarone in the treatment of tachyarrhythmia with congestive heart-failure.Methods Patients with congestive heart failure and tachyarrhythmia（n= 120）were enrolled in this study.They were randomly divided into two groups（observation group and control group）,including 60 patients each.All the patients received regular anti-heart failure treatment.The observation group was given amiodarone orally,whereas the control group was given propafenone hydrochloride orally.The treatment lasted for 4 weeks.NYHA classification and 24h Holter ECG monitoring were recorded before and after the treatment in all the patients.Results The total effective rate was 88.3% and the success rate was 36.6% in the observation group.The difference in the total effective rate between the two groups was statistically significant（P0.05）.None of mortality due to worsened cardiac function was observed during the treatment of amiodarone.Conclusion The efficacy and safety of amiodarone in the treatment of tachyarrhythmia with congestive heart failure were better than those of propafenone hydrochloride.Amiodarone could be used as the preferred anti-arrhythmic agent.

关 键 词：胺碘酮 心律平 心力衰竭 心律失常 

分 类 号：R541.7[医药卫生—心血管疾病]