超敏CRP(hs-CRP)的检测对维持性血透的尿毒症患者心血管事件发生的临床价值研究  

THE CLINICAL SIGNIFECANCE OF DETERMINATION OF HS-CRP FOR CARDIOVASCULAR EVENTS IN UREMIC PATIENTS

作　　者：赵莲英[1] 程征涛 呼金田[1] 刘文利[1] 赵丽珍[1] 王玉芬[1] 

机构地区：[1]河北工程大学附属医院检验科,邯郸056029 [2]河北省卫生监督所

出　　处：《现代预防医学》2010年第23期4529-4530,共2页Modern Preventive Medicine

基　　金：河北省医学科学研究重点课题计划(06062)

摘　　要：[目的]探讨检测超敏CRP对尿毒症患者心血管事件发生的临床意义。[方法]测定136例维持性血透患者透析前后的超敏CRP,随访3年,观察患者心血管事件及死亡事件发生情况,分析其与超敏CRP的关系。[结果]维持性血透尿毒症组患者hs-CRP水平与正常对照组比较差异有统计学意义(P﹤0.05)。维持性血透尿毒症患者中hs-CRP升高组心血管事件发生、心血管事件死亡率、总死亡率与hs-CRP正常组比较差异有统计学意义(P﹤0.05),hs-CRP与患者危险死亡度显著相关。维持性血透尿毒症组hs-CRP阳性率为54%。[结论]hs-CRP是维持性血透尿毒症组心血管事件发生率的危险因素,hs-CRP的检测也有助于判断该组患者的预后。[Objective]To investigate the significance of determination of hs-CRP for cardiovascular events in uremic patients.[Methods]We detected hs-CRP levels in the uremic patients every six months,meanwhile the cardiovascular events and died events were recorded during the follow-up period.[Results]The plasma level of hs-CRP was significantly higher in the uremic patients than those in controls（P﹤0.05）,total mortality rate,cardiovascular mortality rate and frequency of cardiovascular events were higher in the high hs-CRP group than in the normal hs-CRP group（P﹤0.05）.The positive rate of hs-CRP was 54%.[Conclusion]In uremic patients,the increase of hs-CRP is the risk factor for cardiovascular events,and the determination of hs-CRP is also valuable for the prediction of prognosis.

关 键 词：超敏CRP 尿毒症 心血管并发症 

分 类 号：R692[医药卫生—泌尿科学]