帕罗西汀联用黛立新治疗初诊抑郁症的临床对照研究  

CLINICAL CONTROL STUDY OF DEANXIT COMBINED WITH PAROXETINE TREATMENT IN NEWLY DIAGNOSED DEPRESSION

作　　者：刘健[1] 贾应勃 赵蕊[1] 

机构地区：[1]陕西西安电力中心医院内科,西安710032

出　　处：《现代预防医学》2010年第23期4556-4557,共2页Modern Preventive Medicine

摘　　要：[目的]探讨帕罗西汀联用黛立新治疗初诊抑郁症患者的疗效及安全性。[方法]将48例初诊抑郁症患者随机分为研究组(帕罗西汀联用黛立新)和对照组(帕罗西汀)各24例,治疗6周。采用汉密尔顿抑郁量表(HAMD)和不良反应量表(TESS)在治疗前和治疗后1、2、4、6周末进行疗效及副反应评价。[结果]帕罗西汀联用黛立新组总有效率(91.7%)明显高于对照组(62.5%),差异有统计学意义(P﹤0.05);两组HAMD评分比较,第1周末开始研究组明显低于对照组,差异有统计学意义(P﹤0.05);两组TESS总分比较,治疗后1周末对照组明显高于研究组,差异有统计学意义(P﹤0.05),其余时期差异无统计学意义(P﹥0.05)。[结论]帕罗西汀联用黛立新治疗抑郁症有较好疗效,起效快,安全性好。[Objective]To explore the efficacy and safety of Deanxit combined with paroxetine treatment in newly diagnosed depression patients.[Methods]48 patients newly diagnosed with depression were randomly divided into study group（paroxetine combined with Deanxit）and control group（paroxetine）,who were treated for 6 weeks.Hamilton Rating Scale for Depression（HAMD）and Treatment Emergent Symptom Scale（TESS）were used before treatment and 1st,2nd,4th,6th weekend after treatment to evaluate the efficacy and side effects.[Results]The total effective rate in study group（paroxetine combined with Deanxit）was 91.7%,which was significantly higher than that in control group（62.5%）,the difference was statistically significant（P﹤0.05）;HAMD scores at the 1st weekend between the two groups,which in study group was significantly lower in the control group,the difference was statistically significant（P﹤0.05）;TESS scores at the 1st weekend after treatment between the two groups,which in the control group was significantly higher than 1 week study group,the difference was statistically significant（P﹤0.05）,the differences in the rest periods were not statistically significances（P﹥0.05）.[Conclusion]Paroxetine combined with Deanxit treatment for depression has a good effect,fast onset,good security.

关 键 词：帕罗西汀 黛立新 抑郁症 

分 类 号：R971.43[医药卫生—药品]