404例儿童药品不良反应报告分析  

An Analysis of 404 Cases of Child Adverse Drug Reactions

作　　者：彭翠英[1] 何周康[1] 龙荣[1] 胡勤[1] 

机构地区：[1]湖南省儿童医院,湖南长沙410007

出　　处：《儿科药学杂志》2010年第6期31-33,共3页Journal of Pediatric Pharmacy

摘　　要：目的：了解我院药品不良反应（ADR）发生情况及引发ADR的相关因素,促进临床合理用药。方法：对我院2007~2009年收集到的404例ADR进行分类汇总,并加以分析。结果：404例ADR中男275例（68.1%）,女129例（31.9%）;化学药品引起ADR 327例（80.9%）,中成药引起ADR 77例（19.1%）;静脉给药361例（89.4%）。抗微生物药引起的ADR居首位,共41种抗微生物药物引起274例ADR,占总例数的67.8%。皮肤及其附件损害是ADR最主要的表现,占总例数的61.6%（249例）。结论：儿童ADR的发生男孩比女孩多,ADR的发生与给药途径、药品种类等多种因素相关,应加强ADR的监测及相关知识的宣传,以减少和避免ADR的发生。Objective：To study the occurrence of children adverse drug reactions（ADR） in our hospital and its relevant factors in order to improve the rational drug use in the clinic practice.Methods：Four hundred and four ADR cases collected in our hospital during 2007~2009 were categorized and a statistical analysis was performed.Results：Two hundred and seventy-five males took the majority of the total 404 ADR cases（68.1%）,and only 129 cases（31.9%） were female.Three hundred and twenty-seven cases（80.9%） were induced by chemical drugs,and the other 77 cases（19.1%） were induced by traditional Chinese drugs.Most of the 404 ADR cases were induced by intravenous injection,which occupied 89.4%（361 cases）.Antimicrobial drugs were the first category of drugs to cause ADR,for 274 cases（67.8%） were induced by 41 antimicrobials.ADR most commonly manifested themselves in the injury of skin and its appendants,which accounted for 61.6%（249 cases）.Conclusions：Male cases account for the majority of ADR in children.The occurrence of ADR was related to many factors,such as administration route and drug varieties.Strictly monitoring and promoting of ADR knowledge could reduce and avoid the occurrence of ADR.

关 键 词：药品不良反应 不良反应监测 合理用药 儿童 

分 类 号：R965.3[医药卫生—药理学]