自制美沙西汀-甲氧基-^(13)C的表征  

Characterization of Methacetin-methoxy-^(13)C

作　　者：卢伟京[1] 卢浩[1] 杨维成[1] 管樑[2] 朱承谟[2] 刘卫霞[1] 李帅[1] 徐仲杰[1] 陈素芸[2] 姜磊[2] 

机构地区：[1]上海化工研究院,上海200062 [2]上海交通大学医学院附属瑞金医院核医学科,上海200025

出　　处：《同位素》2010年第4期216-220,共5页Journal of Isotopes

基　　金：国家高技术研究发展计划项目(2008AA02Z427)

摘　　要：采用新的方法,以甲醇-13C为原料直接合成了美沙西汀-甲氧基-13C,并对其进行了HPLC、LC-MS和1HMNR等分析。结果表明,所合成的样品是目标产品,产率为70.0%,13C丰度为99%,纯度为99.8%。与经典的合成方法比较,本方法具有较好的经济效益。使用本方法自制的美沙西汀-甲氧基-13C进行小鼠13C-呼吸试验,结果表明,美沙西汀-甲氧基-13C可以在小鼠活体状态下正确评估其损伤和恢复情况。Methacetin-methoxy-^13C was synthesized by using methanol-^13C with a novel method,and the characterization of it was performed using HPLC,LC-MS and ^1HMNR.The results indicated that the synthetic was right.And the yield of methacetin-methoxy-^13C was 70.0% with 99% ^13C abundance and 99.8% purity.Compared with the classical method,there was more benefit.The methacetin ^13C-breath test was performed with the synthetic on the live mice,which showed a precise reflection of alteration of liver function in liver injury and functional recovery.

关 键 词：美沙西汀-甲氧基-13C 13C-呼吸实验 表征 

分 类 号：TQ421.7[化学工程]