HPLC法检测丁草胺合成反应液组分以优化合成工艺  

Determination of Components of Synthesizing Butachlor Reaction by HPLC to Optimize Synthesis Process

作　　者：沈爱宝[1] 吴锦明[1] 李国华 

机构地区：[1]南通大学化学化工学院,江苏南通226007 [2]南通维立科化工有限公司,江苏南通226407

出　　处：《农药》2010年第12期895-897,共3页Agrochemicals

基　　金：南通市科技局工程技术研究中心项目(D2010;D2001008)

摘　　要：采用高效液相色谱法,建立了同时测定丁草胺及其合成原料2-氯-N-(2,6-二乙基苯基)乙酰胺和副产物2,6-二乙基苯胺的方法。用该方法检测丁草胺不同条件下合成的反应液的组分,得到丁草胺合成的最佳工艺和结果:当2-氯-N-(2,6-二乙基苯基)乙酰胺、氯甲基丁基醚、50%氢氧化钠溶液及相转移催化剂TBAB的摩尔比为1∶1.5∶2.1∶0.01,40℃下反应75 min,丁草胺的产率为93.2%。The method of simultaneity determination of butachlor and its material 2-chrolo-N-（2,6-diethylphenyl）acetamide and by-product 2,6-diethylaniline by HPLC was developed.Using this method to monitor components of synthesizing butachlor reaction at different conditions,the optimal process and result were obtained： when 2-chrolo-N-（2,6-diethylphenyl）acetamide,chloromethyl butyl ether,NaOH 50% and phase transfer catalyst TBAB were reacted at a molar ratio of 1∶1.5∶2.1∶0.01,at 40 °C for 75 min,the yield of butachlor was 93.2%.

关 键 词：丁草胺 2-氯-N-(2 6-二乙基苯基)乙酰胺 2 6-二乙基苯胺 HPLC 合成 

分 类 号：TQ450.7[化学工程—农药化工]