氯丙嗪对氯氮平血浓度的影响  

Chlorpromazine's effect on serum clozapine concentration

作　　者：喻东山[1] 高士衡[1] 

机构地区：[1]南京医科大学附属脑科医院,210029

出　　处：《四川精神卫生》1999年第2期73-74,共2页Sichuan Mental Health

摘　　要：目的：探索氯丙嗪对氯氟平血浓度的影响。方法在12例精神分裂症病人固定氯氮平剂量1周后，查氯氮平血浓度作为基础浓度，然后用1周时间加用氯丙嗪，再固定剂量1周后，查氯氮平血浓度作为处理后浓度。结果处理后浓度（527±300μg／L）比基础浓度（302±125μg／L）显著为高（P＜0．02）。结论氯丙嗪能升高氯氮平血浓度。To discover chlorpromazine's effect on serum clozapine concentration. Method Serumclozapine level was measured as basal serum clozapine level when clozapine dose was fixed for one week in12 inpatients with schizophrenia. Then, serum clozapine level was measured as posttreatmented serumclozapine level when added chlorpromazine dose was fixed for one week in above mentioned these inpatients. Result It was significant higher in posttreatmental serum clozapine level(527±300μg/L) thanbasal serum clozapine level(302±125μg) in these patients(t = 2. 976, v = 11, P < 0. 02). ConclusionChlorpromazine can increase serum clozapine level when chlorpromazine combined with clozapine inschizophrenics.

关 键 词：氯丙嗪 氯氮平 血药浓度 精神分裂症 

分 类 号：R971.41[医药卫生—药品] R749.305[医药卫生—药学]