褪黑素对5/6肾切除大鼠残肾炎症反应的抑制作用  

Effect of Melatonin on Inflammation in 5/6 Subtotal Nephrectomized Rats

作　　者：沈延春[1] 周丹 庹新兰[1] 陈琼霞[1] 

机构地区：[1]江汉大学医学院医学系内科教研室,武汉430056 [2]武汉市第八医院内科,430021

出　　处：《医药导报》2010年第12期1549-1551,共3页Herald of Medicine

基　　金：湖北省教育厅科研计划中青年项目(基金编号:Q200734003)

摘　　要：目的观察褪黑素(MEL)对5/6肾切除大鼠残肾炎症反应的抑制作用,探讨其治疗慢性肾衰竭的作用机制。方法建立5/6肾切除大鼠慢性肾衰竭模型。分为假手术(CTL)组、5/6肾切除(STN)组和MEL组,各48只。MEL组灌胃给予MEL5mg·kg-1.d-1,共40周。检测第1,2,4,8,12,16,26和40周共8个不同的时间段单核巨噬细胞浸润的情况。结果 5/6肾切除大鼠残肾肾间质炎性浸润指数显著升高。与STN组比较,MEL组尿蛋白排泄量和间质炎性细胞浸润均显著减少(P<0.05或P<0.01)。结论 MEL能够减少5/6肾切除大鼠尿蛋白排泄量,抑制肾间质炎性细胞的浸润,保护肾功能。Objective To study the effects of long-term administration of melatonin（MEL）on inflammation in subtotally nephrectomized rats and to explore the mechanism.Methods Established a model of subtotal（5/6）nephrectomy（STN）and took melatonin（5 mg·kg-1·d-1）for 40 weeks.The changes of inflammatory cells infiltration（ED-1）at the 1st,2nd,4th,8th,12th,16th,26th and 40th week after operation were detected.Results The indexs of infiltration of inflammatory cells increased on the remnant kidney in STN group,which were lessened in renal interstitiun remarkably（P0.05,P0.01）in MEL group.Conclusion Melatonin has therapeutic effects on inhibiting inflammtion in interstitium by reducing urinary protein excretion.

关 键 词：褪黑素 肾衰竭 慢性 炎症 尿蛋白 大鼠 

分 类 号：R977[医药卫生—药品] R692.5[医药卫生—药学]