硫普罗宁片治疗慢性铅汞中毒的临床疗效  

A clinical study on the efficiency of tiopronin tablets in treatment of chronic lead and mercury roisoning

作　　者：杨波[1] 王曙炎[1] 王萍[2] 

机构地区：[1]河南省医学科学研究所 [2]郑州市公路管理总段卫生所,郑州450052

出　　处：《中国临床药学杂志》1999年第2期78-81,共4页Chinese Journal of Clinical Pharmacy

基　　金：国家"八五"科技攻关项目(合同编号:85-922-02-27).

摘　　要：目的:评价硫普罗宁(Tio)治疗慢性铅、汞中毒的有效性和安全性.方法:选择慢性铅、汞中毒患者45例,随机分为:试验组30例,Tio按200mg,tid po;对照组15例,二巯丁二酸(DMSA)500mg,tid po.疗程均为4wk.结果:试验组痊愈22例(73.3%),好转7例(23.3%),无效1例(3.3%),总有效率为96.7%;对照组痊愈12例(80.0%),好转3例(20%),总有效率达100%.试验组患者仅1例出现轻度恶心、纳差.结论:Tio具有可靠的驱铅、驱汞作用,疗效接近DMSA胶囊,且安全性良好.AIM: To evaluate the efficiency of tiopronin (Tio) tablets in treatment ofchronic lead and mercury poisoning (CLMP)by clinical trial. METHODS:Forty-five patients with CLMP were distributed into 2 groups. Thirty patients in trial group took the Tio tablets po,tid with the dose of 200 mg. Fifteen patients in control group took dimercaptosuccinic acid (DMSA) capsules ,po,tid with the dose of 500 mg. The treatment periods of 2 groups were 4 wk. RESULTS:The main clinical parameters of trial and control groups were as follows. The total efficiency rates were 96. 7% and 100% respectively. The recovered cases were 22 (73.3%) and 12(80%) respectively. The improved cases were 7(23. 3%) and 3(20%) re-spectively. CONCLUSION: The Tio tablets have reliable role of expelling lead and mercury with fine security. Its efficiency is close to that of DMSA capsules.

关 键 词：硫普罗宁 二巯丁二酸 胶囊 慢性 汞中毒 铅中毒 

分 类 号：R595.205[医药卫生—内科学]