江苏省部分地区散发戊型肝炎流行病学及病毒基因型  

Epidemiology and the genotypes of acute sporadic hepatitis E in Jiangsu Province

作　　者：张雪峰[1] 张军[2] 田华[1] 许可[1] 闫强[2] 夏宁邵[2] 朱凤才[1] 

机构地区：[1]江苏省疾病预防控制中心急性传染病防制所,江苏南京210009 [2]厦门大学国家传染病诊断试剂与疫苗工程技术研究中心,福建厦门361005

出　　处：《中华疾病控制杂志》2010年第12期1207-1209,共3页Chinese Journal of Disease Control & Prevention

摘　　要：目的了解江苏省部分地区散发戊型肝炎病例的流行特征及病毒基因型。方法在江苏省部分地区开展为期一年戊型肝炎病例监测,用酶联免疫吸附试验(enzyme-linked immunosor-dent assay,ELISA)对各医疗单位报告的急性肝炎病例进行血清学分型,对其中确诊为急性戊型肝炎病例进行流行病学分析以及戊型肝炎病毒(hepatits E virus,HEV)RNA检测和序列分析。结果男女戊型肝炎病例比例为4.4∶1,84.0%的病例集中在40岁及以上的年龄组,全年均有戊型肝炎病例发生,70.5%的病例集中在上年12月份至次年的4月份间;HEV基因分型检测结果为HEV-1型与HEV-4型,所占比例分别为5.1%、94.9%。结论江苏省戊型肝炎发病比例男性高于女性,多见于40岁以上人群,冬春季节发病较高,戊型肝炎病毒株以HEV-4型为主。Objective To investigate the epidemiological characteristics and the genotype of hepatitis E in Jiangsu Province.Methods Patients with acute sporadic hepatitis were collected,anti-HEV-IgM were tested by commercial ELISA kits,and the RT-PCR method was applied to detect the sequence of HEV.Results Sporadic hepatitis E cases of 84.0% occurred with age over 40,the male to female ratio was 4.4∶1,70.5% cases occurred from December to April;the HEV type 1 and type 4 co-existed,but the HEV type 4 was proved to be the main type（94.9%）.Conclusions The cases with hepatitis E were more frequent in male than in female,most of cases occurred with age over 40,rose up in winter and spring,the HEV type 4 was the main type.

关 键 词：肝炎 戊型 流行病学 基因型 

分 类 号：R181.2[医药卫生—流行病学] R512.65[医药卫生—公共卫生与预防医学]