红景天苷对糖尿病脑病模型大鼠学习记忆功能的影响  

Cognitive function Effect of Salidroside on Diabetic Encephalopathy Rats

作　　者：赵■ 蔺勇[2] 程永杰[2] 张扬[3] 

机构地区：[1]吉林大学第一医院,吉林长春130021 [2]长春市中心医院神经内科,吉林长春130051 [3]吉林大学药学院

出　　处：《中国实验诊断学》2010年第11期1722-1724,共3页Chinese Journal of Laboratory Diagnosis

基　　金：吉林省科技发展计划资助项目(No.200705187)

摘　　要：目的研究红景天苷对糖尿病脑病大鼠的学习记忆功能影响。方法 Wistar大鼠分为3组:正常对照组、糖尿病组及红景天苷组。除正常对照组外,其余两组腹腔注射链脲佐菌素(STZ)诱导制备糖尿病模型。红景天苷组给予50 mg/kg灌胃治疗。用药12 w后,监测大鼠血糖和体质量变化;Morris水迷宫试验测试大鼠学习记忆能力。结果与糖尿病组相比,红景天苷组大鼠血糖浓度降低,体质量增加,学习记忆障碍得以改善。结论红景天苷对糖尿病脑病模型大鼠的学习记忆功能有改善作用。Objective To study the congnitive function effect of salidroside on diabetic encephalopathy rats.Methods Wistar rats were divided into three groups：normal control group,diabetic group and salidroside-treated group.Except for rats in normal control group,the other two group rats were injected streptozotocin（STZ） intraperitoneally to establish the diabetic model.After that,rats were administered salidroside 50 mg/kg for 12 weeks.The level of blood glucose and the body weight were examined.The learning and memory ability was tested by Morris water maze.Results Compared with the diabetic group,the level of blood glucose decreased,the body weight increased and the learning and memory ability improved in the salidroside-treated group.Conclusion Salidroside might develop the cognitive function.

关 键 词：糖尿病 红景天苷 认知功能 

分 类 号：R285.5[医药卫生—中药学]