375例药瘾者庚型肝炎病毒感染状况调查  

The Prevalence of HGV in Drug Users in Hubei Province

作　　者：杨道锋[1] 夏宁邵[2] 田德英[1] 张振刚 雷洪波[1] 虞涤霞 宋佩辉[1] 

机构地区：[1]同济医科大学附属同济医院传染科,武汉430030 [2]厦门大学国家基因工程重点实验室 [3]武汉市第七医院传染科

出　　处：《中西医结合肝病杂志》1999年第2期3-4,共2页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金：国家"九五"攻关;"863"课题资助

摘　　要：目的:调查湖北地区药瘾者HGV感染状况。方法:检查药瘾者的血清HGV感染指标,抗HGV和HGV-RNA分别用ELISA和RT-PCR法检测。结果:375例药瘾者HGV的感染率31.47％(118例)。静脉药瘾者HGV-RNA阳性率32.92％,口服药瘾者为27.96％,两者比较有显著差异(x^2=4.36,P<0.05);女性药瘾者HGV-RNA阳性率(32.84％)高于男性药瘾者(13.46％,X^2=11.55,P<0.01);成瘾时间大于2年者的HGV-RNA阳性率(52.76％),显著高于成瘾时间小于2年者(9.66％,X^2=79.06,P<0.01)。所有HGV感染者的肝功能正常。结论:药瘾者具有较高的HGV感染率。Aim: To survey the prevalence of HGV in the drug users in Hubei province. Methods: Anti-HGV and HGV-RNA were detected by ELISA and RT-PCR.respectively. Results: The positive rate of HGV markers in drug users was 31.47% (118/375). The positive rate of HGV-RNA in Ⅳdrug users (32. 92%) was higher than that in oral users (27. 96% , x2 = 4. 36. P<0. 05). There weren't difference of positive rates of anti-HGV between female drug users (9.23%) and male users (8.65%.x2 = 0.03. P>0.05); between users with positive HBsAg (13.33%) and users with negative HBsAg (9. 37% , x2 = 0. 47. P>0. 05); between female with prostitution (14. 47%) and femae without prostitution (11. 79%, x2 = 0. 37. P>0. 05). However, a difference was found between users addicted for more than 2 years (12. 56%) and users for less than 2 years (6. 25%,x2 = 4. 29. P<0. 05). The positive rate of HGV-RNA in female users (32. 84% ) was higher than that in male users (13. 46 % , x2= 11. 55 . P<0. 01), that in the cases who addicted for more than 2 years (52. 76%) was also higher than those addicted for less than 2 years (9.66%. x2 = 79.06. P<0.01). No abnormality of liver function was found in all of the cases with positive HGV markers. Conclusion: drug addiction increases the risk of HGV infection.

关 键 词：庚型肝炎病毒 药瘾者 流行病学 

分 类 号：R512.630.1[医药卫生—内科学] R595.506[医药卫生—临床医学]