乙型肝炎前S_2抗原/抗体的检测与其病毒标志物的关系及临床意义  

Relationship between the Test of Pre-S_2 Antigen/Antibody and Hepatitis B Virus Markers and the Clinical Significance of the Test

作　　者：高玉金[1] 王国英 

机构地区：[1]江苏省徐州市传染病医院,221004 [2]徐州市肝病研究所

出　　处：《中西医结合肝病杂志》1999年第2期16-18,共3页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

摘　　要：目的:探讨乙型肝炎患者前S_2抗原、前S_2抗体与乙型肝炎病毒标志物(HBV M)之间的关系及临床意义。方法:对176例乙型肝炎患者用ELISA法检测前S_2抗原、前S_2抗体及HBV M;用聚合酶链反应(PCR)法检测乙型肝炎病毒HBV-DNA。结果:急性肝炎、慢性肝炎、肝硬变患者前S_2抗原检出率分别为11.11％、73.73％、75%;前S_2抗体在上述患者中的检出率分别为77.78％、11.02％、5％。前S_2抗原在HBV-DNA、HBeAg阳性病例中的检出率明显高于阴性组(P<0.001)。前S_2抗体阳性病例中,HBV-DNA、HBeAg均为阴性。结论:前S_2抗原的检出意味着病毒有复制或有传染性。前S_2抗体的出现标志着病毒被清除,在慢性肝病中检出并不意味着病情稳定,同时发现该抗体可以在急性乙型肝炎的急性期及血清乙肝病毒标志物全部阴性的患者中检出。Aim: To investigate relationship between the test of Pre-S2 Antigen (Pre-S2Ag), Pre-S2 Antibody (Pre-S2 Ab) and Hepatitis B virus markers (HBV M), the clinical significance of the test. Method; Pre-S2Ag. Pre-S2Ab and HBV M were tested on 176 cases by ELISA; Hepatitis B virus (HBV) DNA was tested by Polymerase Chain Reaction (PCR). Result: Each positive proportion of Pre-S2 Ag in acute hepatitis, chronic hepatitis and cirrhosis cases was 11. 11% , 73. 73% and 75% ; and that of Pre-S2Ab in the above cases was 77.72% . 11. 02% and 5% respectively. The positive proportions of Pre-S2 Ag in positive HBV-DNA and HBeAg cases were obviously higher than those of the negative ones (P<0. 001). In positive Pre-S2 Ab cases, both HBV-DNA and HBeAg were negative. Conclusion: When Pre-S2Ag was found positive, it showed that viruses were reproductive and that positive cases were infectious. When Pre-S2Ab was found positive,it showed that viruses had been eliminated,but not that the condition of chronic hepatitis B cases was stable. The Pre-S2Ab can be found in the acute period of acute hepatitis B cases, and also in those whose HBVM was all negative.

关 键 词：前S2抗原 前S2抗体 乙型肝炎 病毒标志物 

分 类 号：R512.620.4[医药卫生—内科学]