理气止疼与活血止疼治则镇痛作用的比较药理学研究(Ⅰ)——失笑散与金铃子散镇痛作用的研究  

A study of comparative pharmacology of Regulating Vital Energy to Alleviate Pain and Promoting Blood Circulation to Stop Pain on Analgesic Effect in Mice(Ⅰ) The analgesic effect study of Jinlingzisan and Shixiaosan

作　　者：冯前进[1,2] 王世民 冯玛莉[1,2] 武玉鹏[1,2] 杨艳华 

机构地区：[1]山西中医学院 [2]山西省中医药研究院

出　　处：《中国实验方剂学杂志》1999年第3期12-14,共3页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：用实验药理学方法，观察理气止疼方剂金铃子散和活血止疼方剂失笑散对冰醋酸、热板和甲醛－足跖炎性疼痛反应的影响。结果表明，理气止疼方剂金铃子散对冰醋酸以及甲醛－足跖炎性疼痛反应（Ｆ、Ｓ相）均有显著抑制作用，但对热刺激疼痛反应的抑制作用没有统计学差异。活血止疼方剂失笑散对冰醋酸、热板以及甲醛－足跖炎性疼痛的Ｆ相反应有显著抑制效果。The analgesic effect of Jinlingzisan(JLZS,a prescription for analgesic by regulation Qi) and Shixiaosan(SXS,a prescription for analgesic by activate the blood) was observed on the pain like responses and inflammatory pain response that caused by acetic acid,heat and formalin in mice.JLZS showed a potent inhibitory activity on the acetic acid induced writhing and formalin induced F、S phase pain response,but heat induced pain like response was not inhibited significantly.SXS showed a potent inhibitory activity on the acetic acid and heat induced pain like response as well as the formalin induced F phase pain response,but showed no effect significantly on the S phase pain response caused by formalin.From these results,it was concluded that analgesic mechanism of regulating vital energy to alleviate pain and promoting blood circulation to stop pain is different.

关 键 词：失笑散 金铃子散 镇痛 药理学 

分 类 号：R285.5[医药卫生—中药学] R441.1[医药卫生—中医学]