人工合成多表位抗原的研究进展  

Research progress on synthesis of multiepitope antigen

作　　者：张耀光[1] 江莉[1] 

机构地区：[1]上海市疾病预防控制中心,上海市预防医学研究院,200336

出　　处：《国际医学寄生虫病杂志》2010年第6期360-365,共6页International JOurnal of Medical Parasitic Diseases

基　　金：国家自然科学基金（30872211）

摘　　要：通过表位作图、表面展示及计算机预测等技术确定抗原表位的序列，再通过基因工程技术将多个表位串联起来形成多表位抗原。目前，有关多表位抗原的研究已取得长足进步，该文对特异性表位的选择和鉴定、多表位抗原基因的分子设计和合成等方面的研究进展进行了综述。Multiepitope antigen consists of several epitopes which are constructed by different methods including gene synthesis, and it is selected by epitope mapping, surface display and epitope prediction based on the computer technology. Research on muhiepitope antigens has made great progress in recent years. Research progress on the selection and identification of characteristic epitope, the molecular design and the synthesis of mnhiepitope antigen and so on were reviewed in the paper.

关 键 词：多表位抗原 分子设计 基因合成 

分 类 号：R512.62[医药卫生—内科学]