纳米载药系统逆转P-gp介导的肿瘤多药耐药的机制  

Mechanism of nano drug delivery systems in overcoming P-gp mediated multi-drug resistance

作　　者：程林(综述)[1] 程坚[1] 陈宝安(审校)[1] 

机构地区：[1]东南大学医学院附属中大医院血液科,南京210009

出　　处：《国际肿瘤学杂志》2010年第12期903-906,共4页Journal of International Oncology

基　　金：国家自然科学基金资助项目（30740062）;高等院校博士学科专项科研基金资助项目（20070286042）

摘　　要：多药耐药（MDR）是导致肿瘤化疗失败的重要原因,而引起MDR的主要原因为P-糖蛋白（P-gp）过度表达所致的肿瘤细胞内药物浓度下降.纳米载药系统具有靶向性、缓释性以及体内循环时间较长等特点,能通过非特异的胞吞作用、配体修饰的胞吞作用等机制,从蛋白质、基因水平抑制P-gp,有效弥补传统给药方法的不足,从而提高细胞内药物浓度,逆转MDR.Multi-drug resistance （MDR） of cancer cells is a major cause of failure of chemotherapy in cancer treatment. Most MDRs are caused by overexpression of P-glycoprotein （P-gp） which effuses chemotherapeutic agents out of cells. Nano drug delivery systems （NDDS） have been valued for their characteristics including drug targeting, slow-releasing, and long circulation time in the body. Through mechanisms such as non-specific endocytosis and receptor-mediated endocytosis, NDDS can inhibit P-gp at the gene and protein level, leading to improved concentrations of chemotherapeutic drugs in cancer cells, and therefore reverse MDR.

关 键 词：纳米技术 P糖蛋白 抗药性 多药 肿瘤 

分 类 号：R979.1[医药卫生—药品]