厄贝沙坦对2型糖尿病肾病微量白蛋白尿的治疗作用  

Irbesartan in type 2 diabetic nephropathy treatment of microalbuminuria

作　　者：王明岗[1] 

机构地区：[1]河南省商丘市第一人民医院内分泌科,467100

出　　处：《中国临床实用医学》2010年第12期28-29,共2页China Clinical Practical Medicine

摘　　要：目的观察厄贝沙坦合并常规治疗方法治疗2型糖尿病肾病微量白蛋白尿患者的效果。方法将我院80例2型糖尿病肾病微量白蛋白尿患者，随机平均分为两组，在常规降糖、抗凝、降脂、低蛋白饮食治疗的基础上，治疗组：加用厄贝沙坦；对照组：常规治疗未加厄贝沙坦。所有病例于治疗前及治疗3个月、6个月时抽血测定空服血糖（FBG）、餐后血糖（PBG）、内生肌酐清除率（Ccr）、血尿素氮（BUN）、24hUpro、UAER、ACR检测，然后对治疗前后两组分别进行对比分析。结果治疗组2型糖尿病肾病微量白蛋白尿患者，在常规降糖、抗凝、降脂、低蛋白饮食治疗的基础，上加用厄贝沙坦，治疗3个月、6个月后24hUpro、UAER、ACR明显要好于对照组。结论厄贝沙坦治疗2型糖尿病肾病微量白蛋白尿临床疗效显著可靠。Objective To observe irbesartan combined conventional therapy in treating type 2 diabetic patients with microalbuminuria results. Methods 80 cases in hospital with type 2 diabetic patients with mi- croalbuminuria were randomly divided into two groups, in the conventional hypoglycemic, anticoagulant, lipid- lowering, low-protein diet on the basis of the treatment, the treatment group：plus Heuberger losartan; control group ： conventional treatment without irbesartan. All patients before treatment and at 3 months of treatment, at 6 months for blood glucose determination of flight （FBG）, postprandial blood glucose （PBG）, endogenous creati- nine clearance rate（Ccr） , blood urea nitrogen （BUN）, 24 h Upro, UAER, ACR test, then the two groups before and after treatment were analyzed. Results The treatment group of type 2 diabetic nephropathy in patients with microalbuminuria, in the conventional hypoglycemic, anticoagulant, lipid-lowering, low-protein diet based treatment, on the plus irbesartan, treatment for 3 months, 6 months after the 24 h Upro, UAER, ACR signifi- cantly better than the control group. Conclusion Irbesartan treatment of type 2 diabetic microalbuminuria in clinical efficacy and reliable.

关 键 词：2型糖尿病肾病 微量白蛋白尿 厄贝沙坦 

分 类 号：R587.2[医药卫生—内分泌]