金水宝胶囊对慢性肾脏病患者血清胱抑素C与超敏C反应蛋白的影响  

Influence of jinshuibao capsule on serum cystatin C and high sensitive C-reactive protein in chronic kidney disease patients

作　　者：马西臣[1] 谭玉利 顾海东[1] 

机构地区：[1]济宁医学院附属日照市人民医院肾内科,276826 [2]日照市东港区人民医院

出　　处：《中国临床实用医学》2010年第12期32-33,共2页China Clinical Practical Medicine

摘　　要：目的观察金水宝胶囊对慢性肾脏病（CKD）患者血清胱抑素C（CystatinC）与超敏C反应蛋白（hs-CRP）的影响。方法34例明确诊断CKD患者，随机分为对照组（17例）和治疗组（17例），同时选择17名健康成人作为正常对照组，在基础治疗上加用金水宝胶囊3次／d，6粒／次口服，治疗前、后8周分别检测CystatinC、hs-CRP、Scr、BUN。结果CKD患者CystatinC、hs．CRP、Scr较正常对照组明显增高（P〈0．05），常规治疗8周后其CystatinC、hs-CRP、Scr有所降低，但差异无统计学意义（P〉0．05），而加用金水宝胶囊治疗后其CystatinC、hs-CRP、Scr明显降低（P〈0．05）；CystatinC与hs—CRP呈正相关，CystatinC与GFR呈负相关。结论金水宝胶囊可改善早期CKD患者的肾功能和炎症状态，有利于延缓CKD的进展。Objective To observe the influence of jinshuibao capsule on serum cystatin C and high sensitive C-reactive （hs-CRP）protein in chronic kidney disease patients （CKD）. Methods Thirty-four cases CKD patients were randomly divided into two groups： control group （17 cases）and treatment group （treatment with jinshuibao capsules, 17 cases）. Meanwhile, 17 healthy adults were taken as the normal control. The blood concentrations of cystatin C, hs-CRP, Scr and BUN were determined. Results The level of cystatin C, hs-CRP, Scr in all CKD patients were significantly higher than those in the normal control（ P 〈 0. 05 ）, the level of cysta- tin C, hs-CRP, Scr decreased after 8 weeks of conventional treatment （P 〉 0. 05 ）, while those significantly decreased addition of jinshuibao capsule treatment（ P 〈 0. 05 ） ; Cystatin C and hs-CRP were positively correlated, but Cystatin C was negatively correlated with GFR. Conclusion The renal function and inflammation can be alleviated by jinshuibao capsule in early CKD patients, which could be slowed the progression of CKD.

关 键 词：金水宝胶囊 慢性肾脏病 胱抑素C 超敏C反应蛋白 

分 类 号：R692[医药卫生—泌尿科学]