培美曲塞治疗老年晚期非小细胞肺癌疗效观察与护理  

Observation of treatment and nursing care for pemetrexed treatment of advanced non-small cell lung cancer

作　　者：郑玉秀[1] 赵凤晓 孟令新[1] 

机构地区：[1]济宁医学院附属日照市人民医院肿瘤科／日照市肿瘤治疗中心,262826 [2]五莲县人民医院肿瘤科

出　　处：《中国临床实用医学》2010年第12期212-214,共3页China Clinical Practical Medicine

基　　金：济宁医学院面上项目资助/日照市人民医院博士科研启动基金资助项目（项目编号：080901）

摘　　要：目的观察培美曲塞治疗老年晚期非小细胞肺癌的疗效和毒副反应，探寻相对应的护理方法。方法通过对32例老年晚期非小细胞肺癌患者静滴培美曲塞，观察其疗效、毒副反应，并实施相应护理措施。结果32例晚期非小细胞肺癌患者应用培美曲塞治疗，完全缓解（CR）2例，部分缓解（PR）17例，稳定（SD）6例，进展（PD）7例。发生的毒副反应主要有骨髓抑制、消化道反应、过敏反应及药物外渗等。其中2例Ⅱ度骨髓抑制，1例Ⅳ度骨髓抑制；11度恶心呕吐19例，5例轻度便秘；2例出现严重皮肤瘙痒。经采取有效的对症治疗及积极的护理措施后都得到了缓解。结论培美曲塞治疗晚期非小细胞肺癌患者，掌握正确的给药方法，及时进行毒副反应的处理和护理干预，能有效地提高患者生活质量。Objective To observe the pemetrexed treatment of advanced non-small cell lung cancer and toxicity, corresponding to explore nursing. Methods 32 cases of elderly patients with advanced non-small cell lung cancer patients were infused pemetrexed in order to evaluate efficacy, toxicity, and implement appro- priate care measures. Results 32 patients with advanced non-small cell lung cancer patients with pemetrexed treatment, complete remission （CR）2 patients and partial remission （PR）17 cases, stable （SD）6 cases and progress （PD）7 cases. Toxicity occurs mainly in bone marrow suppression, gastrointestinal reactions, allergic reac- tions and drug extravasation and so on. 2 cases Ⅱ myelosuppression, 1 Ⅳ myelosuppression; -Ⅱ nausea and vomiting in 19 cases, 5 cases of mild constipation; 2 patients had severe skin itching. The effective symptomatic treatment and active care measures have been eased. Conclusion Pemetrexed treatment of advanced non-small cell lung cancer patients, master the correct method of administration, toxicity of timely symptomatic treatment and care interventions can improve the quality of life of patients.

关 键 词：培美曲塞 晚期非小细胞肺癌 毒副反应 护理 

分 类 号：R473.73[医药卫生—护理学]